抗苗勒管激素和甲状腺自身免疫抗体水平对体外受精-胚胎移植临床结局影响的研究

Effects of anti-Mullerian hormone and antithyroid autoantibody on the clinical outcome of in vitro fertilization and embryo transfer

目的探究抗苗勒管激素(AMH)和甲状腺-抗体水平对体外受精-胚胎移植临床结局的影响。方法选取大理大学第一附属医院生殖医学科行体外受精-胚胎移植的患者174例,对其促排卵前的AMH水平和甲状腺抗体情况进行分析。结果 AMH>4.17ng/mL的患者比AMH≤4.17ng/mL的两组患者有更高的获卵数,差异均有统计学意义(P<0.05)。甲状腺自身免疫抗体阳性患者的流产率(16.4%)明显高于甲状腺自身免疫抗体阴性的患者(6.9%),差异有统计学意义(P<0.05)。结论 AMH水平与患者的促排卵结局关系密切,可作为制订治疗方案的重要参考。应提高对甲状腺自身免疫抗体阳性不孕症患者的重视,在其妊娠过程中注意防止流产。

Objective To investigate the effect of anti-Mullerian hormone and antithyroid autoantibody on the clinical outcome of in vitro fertilization and embryo transfer. Methods A total of 174 patients who have received the treatment of in vitro fertilization and embryo transfer were enrolled in the Department of Reproductive Medicine at the First Affiliated Hospital of Dali University.Analyze their levels of anti-Mullerian hormone and antithyroid autoantibody before controlled ovarian hyperstimulation（COH）. Results Patients with anti-Mullerian hormone levels 〉4.17 ng/mL had more oocytes collected than the two groups with anti-Mullerian hormone levels ≤4.17 ng/mL （ P 〈0.05）.The abortion rate of antithyroid autoantibody-positive patients （16.4%） was significantly higher than those antithyroid autoantibody-negative patients （6.9%）, P 〈0.05. Conclusion The anti-Mullerian hormone levels are closely related to the patient′s COH outcome and can be used as an important reference to the treatment.We should pay more attention on antithyroid autoantibody-positive patients and avoid abortion during pregnancy.