摘要
目的探讨尿视黄醇结合蛋白(U-RBP)水平与非酒精性脂肪性肝病(NAFLD)的相关性。方法选取2016年4-7月该院体检中心2 121例无症状体检者为研究对象,根据腹部超声诊断结果分为NAFLD组721例,非NAFLD组1 400例。测定U-RBP水平及其他相关实验室参数进行比较。结果NAFLD组的U-RBP水平显著高于非NAFLD组,差异有统计学意义(P<0.05),且随着U-RBP水平的增加NAFLD患病率也逐步上升(χ~2=2 803.518,P<0.05);采用多元逻辑回归分析U-RBP与NAFLD的相关性,发现U-RBP是NAFLD的独立危险因素(OR=2.090;95%CI:1.621~2.694;P<0.05)。结论 U-RBP是NAFLD的独立危险因素。
Objective To investigate the correlation between urinary retinol binding protein(U-RBP) and nonalcoholic fatty liver disease(NAFLD). Methods A total of 2 121 healthy physical examinations were first included in the physical examination of the First Affiliated Hospital of Zhejiang University Medical College from April 2016 to July.According to the results of abdominal ultrasound,the patients were divided into two groups:the NAFLD group(721 cases) and non NAFLD group (1 400 cases),U-RBP and other clinical and laboratory parameters were measured. Results NAFLD patients had significant higher U-RBP than non NAFLD patients( P 〈0.05).and these levels were positively associated with both NAFLD prevalence and severity ( χ^2= 2 803.518 , P 〈0.05).Multivariable regression analysis showed that U-RBP was independently associated with risk for NAFLD ( OR =2.090;95% CI :1.621-2.694; P 〈0.05). Conclusion U-RBP is an independent risk factor for NAFLD.
作者
叶孔钊
赵莹
张娟文
唐朝红
张丽
YE Kongzhao;ZHAO Ying;ZHANG Juanwen;TANG Chaohong;ZHANG Li(Clinical Laboratory,the First Affiliated Hospital of Zhejiang University Medical College,Hangzhou,Zhejiang,310003,China)
出处
《检验医学与临床》
CAS
2018年第22期3356-3359,共4页
Laboratory Medicine and Clinic
基金
浙江省教育厅基金项目(Y201636519)
关键词
尿视黄醇结合蛋白
非酒精性脂肪性肝病
胰岛素抵抗
代谢综合征
urinary retinol binding protein
nonalcoholic fatty liver disease
insulin resistance
metabolic syndrome