健脾固肾化瘀组方联合前列地尔治疗糖尿病肾病临床期患者的临床效果

Clinical Observation on the Treatment of Diabetic Nephropathy at Clinical Stage by Jianpi Gushen Huayu Decoction Combined with Alprostadil

目的:观察健脾固肾化瘀组方联合前列地尔治疗临床期糖尿病肾病患者的临床疗效。方法:选取2016年1月至2017年1月沧州中西医结合医院收治的糖尿病肾病临床期患者100例,按照随机数字法随机分为对照组和观察组,每组50例,对照组患者给予常规治疗,给予前列地尔治疗。观察组在对照组治疗方案基础上给予健脾固肾化瘀组方。观察2组中医证候评分、临床疗效、肾功能以及血糖变化情况。结果:2组治疗前中医证候评分差异无统计学意义(P> 0. 05),治疗后都有所降低,但观察组评分低于对照组,差异有统计学意义(P <0. 05);观察组总有效率为96. 00%,明显高于对照组的80. 00%,差异有统计学意义(P <0. 05); 2组治疗前24 h尿蛋白定量(24 h PRO)、微量尿蛋白(m Alb)、血肌酐(Scr)、尿素氮(BUN)、肾小球率过滤(GFR)比较,差异无统计学意义(P> 0. 05),治疗后观察组24 h PRO、m Alb、Scr、BUN低于对照组,而GFR高于对照组,差异有统计学意义(P <0. 05); 2组治疗后与治疗前比较均有所改善,但差异无统计学意义(P>0. 05)。结论:健脾固肾化瘀组方联合前列地尔对于临床前糖尿病肾病具有良好疗效,能够明显改善患者临床症状和肾脏功能,提高临床疗效。

Objective：To observe the clinical efficacy of Jianpi Gushen Huayu Decoction combined with alprostadil in the treatment of diabetic nephropathy. Methods ：A total of 100 patients with diabetic nephropathy in clinical period in Hospital of Integrated Traditional Chinese and Western Medicine from January 2016 to January 2017 were randomly selected for clinical study. The patients were divided into the observation group and the control group by random number method, with 50 eases in each group. The control group received routine treatment and was treated with alprostadil. The observation group was given the Jianpi Gushen Huayu Decoction on the basis of the same treatment of the control group. The Traditional Chinese Medicine （TCM） symptonl score, clini- cal efficacy, renal function and blood glucose changes of the two groups were observed. Results ： Scores of TCM symptonls in the two groups of patients before treatment had no significant difference,and were decreased after treatment, but scores of the observation group were lower than those of the control group; the total effective rate of observation group was 96% , which was significantly higher than that of 80% of the control group ; there were no significant differences of concentrations of 24 hPRO, mAlb, Ser, BUN, GFR in two groups of patients before treatment,which were decreased after treatment. Concentrations of 24 hPRO,mAlb, Scr, BUN of the observation group were lower than those of the control group ,while concentrations of GFR was higher than that of the control group ; the two groups of patients were improved after treatment compared with before treatment, but there were no significant differenees between the groups. Conclusion ：The combination of Jianpi Gushen Huayu Decoction and alprostadil has good curative effect on diabetic nephropathy, and can improve the clinical symptoms and renal function, and the clinical efficacy.