宣肺平喘方对哮喘TGF-β1、Smad2、Smad7水平的影响研究

Study on the Effect of Lung Regulating and Asthma Relieving Recipe on the Levels of TGF-β1,Smad2 and Smad7 in Asthma

目的:观察宣肺平喘方对哮喘患者的治疗效果,及对TGF-β1、Smad2、Smad7水平的影响。方法:选取2016年3月至2017年3月广元市第二人民医院收治的哮喘患者80例为研究对象,根据其治疗方式分为对照组和观察组,每组40例,对照组给予常规药物治疗,观察组在此基础上给予宣肺平喘方治疗。观察2组患者的治疗效果,比较2组患者治疗前后肺功能、炎性反应因子、TGF-β1、Smad2、Smad7水平的差异。结果:观察组患者治疗的有效率为97. 50%,明显高于对照组(χ2=5. 000,P=0. 025); 2组患者治疗前肺功能指标无差别,治疗后,观察组患者肺功能指标优于对照组; 2组患者治疗前炎性反应因子水平无差别,治疗后,观察组IL-6、hs-CRP和TNF-α水平均低于对照组; 2组患者治疗前TGF-β1、Smad2、Smad7水平无差别,治疗后,观察组TGF-β1、Smad2、Smad7水平均低于对照组。结论:宣肺平喘方对哮喘有较好的治疗效果,可明显改善患者的TGF-β1、Smad2、Smad7表达水平和肺功能,具有良好的临床应用价值。

Objective：To observe the therapeutic effect and the influence of Smad7 on the levels of TGF-β1 ,Smad2 and protein in the treatment of asthma. Methods：Asthma patients treated in our hospital from March 2016 to March 2017 were selected as the research object, according to the treatment methods are divided into control group and observation group, the control group was given routine drug treatment, the observation group was given Xuanfei Pingchuan decoction treatment. The therapeutic effects of the two groups were observed, and the differences of lung function, inflammatory factors ,TGF-beta 1, Smad 2 and Smad7 levels between the two groups before and after treatment were compared. Results ：The effective rate of the observation group was 97. 50%, which was higher than that of the control group （χ^2 = 5. 000, P = 0. 025 ） ; There was no difference in lung function between the two groups before treatment. After treatment, the lung function index of the observation group was better than that of the control group; Two groups of patients had no difference between the levels of proinflammatory cytokines, after treatment, the observation group IL-6, hs- CRP and TNF-alpha water were lower than those in control group; The levels of TGF-, beta 1 ,Smad2 and Smad7 in the two groups before treatment were not different. After treatment, the levels of TGF-, beta 1, Smad2 and Smad7 in the observation group were lower than those in the control group. Conclusion：The method of clearing lung and relieving asthma has better therapeutic effect on asthma. It can obviously improve the expression level of TGF-, beta 1, Smad2, Smad7 and lung function in patients with asthma, and has good clinical value.