补血强肾方联合西药治疗慢性再生障碍性贫血患者的临床效果及对红细胞、白细胞介素的影响

Effect of Buxue Qiangshen Fang Combined with Western Medicine on Chronic Aplastic Anemia and Observation Study on Erythrocyte and Interleukin

目的:研究自拟补血强肾方联合西药治疗慢性再生障碍性贫血患者的临床效果及对患者的红细胞及白细胞介素的影响。方法:选取2014年6月至2015年12月间收治的慢性再生障碍性贫血患者46例作为研究对象,将患者随机均分为对照组与观察组,每组23例,对照组采取单纯西药治疗,观察组在对照组的基础上联合自拟补血强肾方治疗,治疗2个疗程后评估并比较2组疗效,观察治疗前后2组红细胞计数、网织红细胞、血红蛋白水平、骨髓增生,血清白细胞介素表达。结果:观察组临床治愈率为82. 61%,总有效率为95. 65%;对照组临床治愈率为56. 52%,总有效率为78. 26%;观察组临床疗效优于对照组,差异有统计学意义(P <0. 05)。与治疗前比较,治疗后2组RBC、RET、Hb均有所改善,差异有统计学意义(P <0. 05);治疗后观察组RBC、RET、Hb均优于对照组,差异有统计学意义(P <0. 05)。与治疗前比较,治疗后2组患者血清IL-17、IL-6、IL-23均有所下降,差异有统计学意义(P <0. 05);治疗后观察组IL-17、IL-6、IL-23均明显低于对照组,差异有统计学意义(P <0. 05)。治疗后观察组患者骨髓增生显著优于对照组,差异有统计学意义(P <0. 05)。RBC、Hb与临床疗效间呈高度负相关(P <0. 05),IL-23、IL-17、IL-6与临床疗效间正相关(P <0. 05)。结论:补血强肾方联合西药治疗慢性再生障碍性贫血疗效确切,能够有效改善红细胞及白细胞介素的表达。

Objective：To study the self-made Buxue Qiangsheng Fang combined with western medicine in the treatment of chronic aplastie anenfia, and the effects on patients＇ erythroeyte and interleukin. Methods：A total of 46 cases of chronic aplastie anenfia patients in our hospital from June 2014 to December 2015 were selected as the objects of study. All patients were randomly divided into control group and observation group. The control group took western medicine treatment, and the observation group was added self-made Buxue Qiangsheng Fang for treatment. After two courses of treatment, the efficacy of the two groups before and after treatment were evaluated and compared. Red blood cell count, retieuloeyte and hemoglobin levels, bone marrow hyperplasia degree, the expression level of serum interleukin factor of two groups were observed before and after treatment. Results ： The clinical cure rate of the observation group was 82. 61%, and the total effective rate was 95.65%. The clinical cure rate of the control group was 56. 52%, and the total effective rate was 78.26%. The clinical curative effect of the observation group was better than that of the control group （P 〈 0. 05）. After treatment, RBC, RET, Hb of two groups were improved, and the difference was sig- nificant when compared within groups （P 〈 0. 05）. After treatment, RBC, RET, Hb of the observation group were better than the control group （P 〈0. 05）. After treatment, the serum IL-17, IL-6, IL-23 were decreased in the two groups, and the difference was significant when compared within groups （P 〈 0. 05）. After treatment, the IL-17, IL-6, IL-23 in the observation group were significantly lower than those in the control group （ P 〈 0. 05 ）. After treatment, the observation group was significantly better than the control group （P 〈0. 05）. RBC, Hb and clinical efficacy were highly negative correlated （P 〈0. 05）, and IL-23, IL-17, IL- 6 and clinical efficacy were highly positive correlated （ P 〈 0. 05 ）. Both were statistically significant. Conclusion ： Buxue Qiangsheng Fang combined with western medicine has definite effect in the treatment of chronic aplastie anemia, which can effectively im- prove the expression level of red blood cells and interleukin factors.