奥美拉唑联合阿莫西林、呋喃唑酮治疗幽门螺杆菌感染的效果

Effect of Omeprazole combined with Amoxicillin and Furazolidone in the treatment of Helicobacter pylori infection

目的观察奥美拉唑联合阿莫西林、呋喃唑酮治疗幽门螺旋杆菌感染的临床效果。方法选择我院2016年2月～2018年3月收治的幽门螺旋杆菌阳性消化性溃疡或胃炎患者80例,将其随机分为两组,每组40例。对照组给予奥美拉唑20 mg,阿莫西林1.0 g,甲硝唑400 mg,均每日2次;观察组给予奥美拉唑20 mg,阿莫西林1.0 g,呋喃唑酮100 mg,均每日2次。两组患者均服用1周。对比分析两组患者的胃肠道症状改善情况、临床疗效、不良反应发生率等。结果观察组的溃疡愈合率和幽门螺旋杆菌根除率分别为87.50%、92.50%,分别明显高于对照组的65.00%、70.00%(P<0.05)。观察组的总有效率为92.50%,明显高于对照组的72.50%(P<0.05)。观察组和对照组的成本-效果比(C/E)分别为2.62、3.49,观察组的成本效果低于对照组(P<0.05)。结论奥美拉唑联合阿莫西林、呋喃唑酮治疗幽门螺杆菌感染可促进溃疡愈合,有效根除幽门螺杆菌,临床效果显著,且治疗费用低。

Objective To observe the clinical effect of Omeprazole combined with Amoxicillin and Furazolidone in thetreatment of Helicobacter pylori infection. Methods A total of 80 patients with peptic ulcer or gastritis of positive Helicobacter pylori treated in our hospital from February 2016 to March 2018 were selected and they were randomly divided into the two groups, and each group had 40 cases. The control group was given Omeprazole of 20 mg, Amoxicillin of1.0 g, and Metronidazole of 400 mg, 2 times a day. The observation group was given Omeprazole of 20 mg, Amoxicillinof 1.0 g, and Furazolidone of 100 mg, 2 times a day. Patients in the two groups were treated for 1 week. The improvement of gastrointestinal symptoms, clinical efficacy and incidence of adverse reactions and so on were compared andanalyzed between the two groups. Results The ulcer healing rate and eradication rate of Helicobacter pylori in the observation group were 87.50% and 92.50% respectively, which were obviously higher than those of the control group（65.00% and 70.00% respectively） （P〈0.05）. The total effective rate of the observation group was 92.50%, which was obviously higher than that of the control group （72.50%） （P〈0.05）. The cost-effectiveness ratio （C/E） of the observation group and the control group was 2.62 and 3.49 respectively. The cost-effectiveness of the observation group was lowerthan that of the control group （P〈0.05）. Conclusion Omeprazole combined with Amoxicillin and Furazolidone in the treatment of Helicobacter pylori infection can promote ulcer healing and effectively eradicate Helicobacter pylori. The clinical effect is significant and the treatment cost is low.