4-芳硫基吡喃酮类化合物的合成研究

Study of synthesis of 4-arylthio-2H-pyran-2-one derivatives

4-芳硫基吡喃酮类化合物作为有机合成中间体及药物合成中重要的结构单元,广泛应用于药物、染料、功能性材料等领域.采用4-羟基吡喃酮和苯硫酚为反应底物,三乙胺(Et3N)为碱,以二氯甲烷(DCM)为反应溶剂,在25℃下搅拌6小时,经过碳氧键断裂,以65%～88%的收率获得10种4-芳硫基吡喃酮类化合物.通过核磁共振氢谱、碳谱,高分辨质谱,X-射线单晶衍射对其结构进行表征.该合成方法底物适用性好、收率优良、操作简单,具有良好的应用价值.

4-Arylthiopyrone derivatives are widely used in and other fields as organic synthesis intermediates and medicine, dyes, functional materials significant structural units in drug synthesis. In this paper, 4- hydroxy 2H pyran 2 one and benzenethiol were used as reaction substrates,triethylamine （Et3N） as base,dichloromethane （DCM） as reaction solvent, stir ring at 25 ℃ for 6 hours,and carbon oxygen bond was cleavaged. 10 of 4- arylthiopyrone corn pounds were obtained in 65%-88% yield. The structure was characterized by 1H NMR,13C NMR, HRMS and X ray single crystal diffraction. The synthetic method was with excellent applicability,favorable yield, simple operation and applied potential.