人类工作记忆的N-back和DMTS范式脑功能影像的Meta分析

Meta-analysis of brain functional images under N-back and DMTS paradigm in human working memory

目的研究工作记忆N-back和DMTS范式的大脑激活异同。方法通过关键词检索BrainMap功能数据库，共得到122篇文献中的其122个试验，其中67个N-back试验，共937个被试、900个激活点；55个DMTS试验，共806个被试、872个激活点。后基于蒙特利尔神经研究所（MNI）空间的坐标采用FDRPN（P〈0．0001）方法分析。结果在N-back和DMTS范例的融合中激活双侧大脑的下顶叶（左：-36，-52，44；右：38，-52，48）和岛叶（左：-34，22，0；右：34，24，2）、左脑的额上回（2，16，50）和额下回（-44，8，30），右脑的额中回（46，36，24）和下回（30，4，56）。N-back范式与上述结果相似，而DMTS范式仅激活左脑中央前回（-50，8，34）和右脑岛叶（34，24，4）。结论额叶-顶叶是工作记忆的神经环路，N-back范式的大脑激活基本与工作记忆的神经环路贴合，但DMTS范式大脑激活区域较少，无法准确体现工作记忆的神经环路。

Objective To study the similarities and differences in brain activation under N-back and DMTS paradigms of working memory. Methods Through searching of BrainMap function database by the combination keywords, a total of 122 articles with 122 experiments （ N-back： 67 experiments, 937 subjects,900 foci; Delayed Matched to Sample ： 55 experiments, 806 subjects, 872 foci）. Maps were analyzed using the FDR PN （P〈0. 0001 ） method based coordinates of the Montreal Neurological Institute （MNI） space. Results In the combine of the N-back and DMTS paradigms,these regions were activated including the bilateral inferior parietal lobe （Left： -36,-52,44; Right： 38,-52,48） and insula（Left：-34,22,0; Right ： 34,24,2 ）, the superior frontal gyrus （ 2,16,50） and inferior frontal gyrus （- 44,8,30） of the left brain, and the middle frontal （46,36,24） and sub-gyral （30,4,56） of the right brain. The N-back paradigm was similar to the above results, whereas the DMTS paradigm only activated the precentral gyrus （-50,8, 34） of the left brain and the right insula （34,24,4）. Conehmion The neural circuit of working memory is the frontal-parietal networks. N-back paradigm with the brain activation consists to the neural circuit of working memory. However, DMTS paradigm activates less brain regions and is inconsistent to the neurons of working memory.