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临清市2015-2017年疑似预防接种异常反应监测分析 被引量:1

Monitoring and analysis of adverse events following immunization in Linqing city from 2015 to 2017
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摘要 目的近年来媒体接连报道的疫苗事件,使公众对接种疫苗后出现的各种不良反应关注度增加。通过分析临清市2015-2017年疑似预防接种异常反应(adverse events following immunization,AEFI)发生的特征,评价AEFI监测工作开展情况和疫苗的安全性。方法通过中国疑似预防接种异常反应信息管理系统收集临清市2015-2017年上报的AEFI个案数据,采用Excel 2007对AEFI特征及相关指标进行描述性统计学分析。结果 2015-2017年临清市共报告AEFI个案549例,一般反应546例,主要为发热、红肿、硬结,占99.46%;异常反应2例,均是由接种卡介苗引起的卡介苗淋巴结炎,占0.36%;偶合反应1例,占0.18%。男女性别比1.05∶1,≤1岁儿童占65.76%,96.72%发生于接种后≤1d;涉及20种疫苗,报告发生率居前3位的疫苗依次为无细胞百白破(162.03/10万)、乙脑减毒疫苗(145.26/10万)和A群流脑疫苗(104.89/10万)。2015-2017年每年度AEFI报告发生率分别为59.57/10万、72.70/10万和65.93/10万,累计报告发生率为66.09/10万。报告病例全部治愈或好转,无死亡病例。结论 2015-2017年临清市AEFI监测系统运转平稳正常。AEFI报告病例主要以小年龄组、接种后≤1d出现一过性的一般反应为主,疫苗接种工作安全可靠。 OBJECTIVE In recent years,a series of vaccine incidents reported by the media has increased the public's attention to various adverse reactions after vaccination.This study analyzed the characteristics of the adverse events following immunization(AEFI)in Linqing from 2015 to 2017,as to evaluate the development of AEFI monitoring and the safety of the vaccine.METHODS The AEFI case data reported from 2015 to 2017 were collected through the AEFI Information Management System,and the AEFI characteristics and related indicators were analyzed by Excel 2007.RESULTS From 2015 to 2017,a total of 549 cases of AEFI cases were reported in Linqing,with 546 cases of general reaction,mainly fever/red swelling/induration,accounting for 99.46%;The abnormal reaction of 2 cases was caused by Bacille Calmette-Guerin vaccination,accounting for 0.36%.The coupling reaction was 1 case,accounting for 0.18%.The sex ratio of male and female is 1.05∶1,the proportion of children not more than 1 years old was 65.76%,and 96.72%of the cases occurred not more than 1 dafter inoculation.Among the 20 vaccines,the first three vaccines with the highest incidence rate were ADPT(162.03/100 000),the attenuated JE vaccine(145.26/100 000),and the Group A epidemic cerebrospinal meningitis vaccine(104.89/100 000).The incidence of AEFI reported in each year was 59.57/100 000,72.70/100 000,65.93/100 000,and the cumulative incidence of reports was 66.09/100 000.All cases were cured or improved without death.CONCLUSIONS The operation of AEFI monitoring system in Linqing from 2015 to 2017 is stable and normal.The AEFI reports are mainly the general reactions of the children in small age group occurred after inoculation not more than 1 day.
作者 徐金芳 郭贾莉 宋海燕 XU Jin- fang , GUO Jia-li , SONG Hai-yan(Center for Disease Prevention and Control of Linqing, Linqing 252600, P. R. China)
出处 《社区医学杂志》 2018年第14期1123-1127,共5页 Journal Of Community Medicine
关键词 疑似预防接种异常反应 疫苗 监测 adverse events following immunization vaccines monitoring
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