炎性因子与其他抑郁相关因素关系的研究现状

Current situation of relationship between inflammatory factors and other depression-related factors

抑郁症作为精神科常见疾病之一,是一种以持久的低落心态为主的情感障碍综合征。临床上表现为意志消沉、自卑厌世和有自杀企图等行为,其发病机制较为复杂。其相关发病机制主要有炎症假说、单胺类神经递质假说、下丘脑-垂体-肾上腺轴(HPA)假说与脑源性神经营养因子(BDNF)假说。其中,炎症假说对抑郁发生发展起着非常重要的作用。本文针对炎症假说和其他假说之间的关系做一综述。

Depression as one of the psychiatric common diseases,which is mainly composed of persistent low mentality is a kind of emotional disorders syndrome,clinical expression is depressed,self-abased blase,suicide attempts,etc,its pathogenesis is unclear. The pathogenesis of this disease is the inflammatory hypothesis,monoamine neurotransmitter hypothesis,hypothalamic-pituitary-adrenal axis（ HPA） hypothesis,and brain-derived neurotrophic factor（ BDNF） hypothesis. The inflammatory hypothesis plays a very important role in the development of depression. This article reviews the relationship between the inflammatory hypothesis and other hypotheses.