氨肽酶N荧光探针的研究进展

Progress in Fluorescent Probes for Aminopeptidase N

氨肽酶N(aminopeptidase N,APN)是一种外肽酶,广泛存在于哺乳动物体内,可从蛋白质多肽链的N末端水解中性或碱性氨基酸,在人体中具有多种重要的生理功能。APN可作为癌症诊断的标志物,尿液中APN也可作为肾小球肾炎的早期生物标志物。本文综述了APN荧光探针的研究进展,主要包括亲和力型APN荧光探针和反应型APN荧光探针,并对它们的优缺点进行了比较;最后对APN荧光探针的发展前景进行了展望。

Aminopeptidase N（APN） is an exopeptidase that widely exists in the body of mammals. It is recognized to have various physiological functions in human body. Herein,the development of fluorescent probes for aminopeptides N was reviewed and generally divided into two categories： affinity based fluorescent probes and reaction based fluorescent probes, with their advantages and shortcomings compared, which may illuminate the future development of APN fluorescent probes.