(R)-3-氨基丁醇的合成研究进展

Progress in the Synthesis of (R)-3-Amino-1-butanol

(R)-3-氨基丁醇是合成抗艾滋病整合酶抑制剂度鲁特韦的重要中间体,其品质的好坏以及价格的高低对于度鲁特韦的品质及生产成本有着很重要的影响。本文从化学拆分法、手性原料合成、化学诱导法、制备色谱法和生物酶法五个方面对合成(R)-3-氨基丁醇的方法进行了综述。

As a key intermediate for the synthesis of HIV intergrase inhibitors dolutegravir,the quality and price of（R）-3-amino-1-butanol have a significant impact on the quality and production cost of dolutegravir. In this paper,the synthesis of（R）-3-amino-1-butanol was reviewed from five aspects： chemical resolution,chiral synthesis,chemical induction,preparative chromatograph and enzymatic hydrolysis.