奥美拉唑联合阿莫西林、甲硝唑治疗消化性溃疡效果观察

Effect Observation of Omeprazole Combined with Amoxicillin and Metronidazole in Treatment of Peptic Ulcer

目的研究奥美拉唑联合阿莫西林、甲硝唑治疗消化性溃疡的临床效果。方法分为观察组和对照组两组,治疗对象选自我院从2017年4月至2018年4月收治的76例消化性溃疡患者,每组各38例。其中对照组患者进行雷尼替丁联合呋喃唑酮治疗,研究组患者进行奥美拉唑联合阿莫西林、甲硝唑治疗。将两组患者的临床疗效与不良反应发生情况进行比较。结果研究组总有效率(94.74%)显著高于对照组(71.05%),研究组的不良反应发生率(8.33%)明显少于对照组(26.32%),两组存在差异,具有统计学意义。结论奥美拉唑联合阿莫西林、甲硝唑治疗消化性溃疡的临床效果显著,值得临床广泛应用。

Objective to study clinical effect of omeprazole combined with amoxicillin and metronidazole in treatment of peptic ulcer. Methods divide patients into two groups： observation and control group, choose 76 cases peptic ulcers patients from April 2017 to April 2018 in our hospital as treatment objects, 38 cases in each. Control group was treated with ranitidine and furazolidone, and study group with omeprazole combined with amoxicillin and metronidazole. Compare clinical effect and adverse reactions of two groups. Results total effective rate of study group（94.74%） was significantly higher than control group（71.05%）, and adverse reactions incidence of study group（8.33%） was significantly less than control group（26.32%）, difference showe statistical significance between two groups. Conclusion omeprazole combined with amoxicillin and metronidazole has significant clinical effect in treatment of peptic ulcer, which is worthy of wide clinical application.