苯磺酸氨氯地平和氯沙坦钾联合治疗非杓型高血压患者清晨高血压疗效观察及安全性分析

Effect Observation and Safety Analysis of Amlodipine Besylate Combined with Losartan Potassium in Treatment of Morning Hypertension of Non-dipper Hypertension Patients

目的分析苯磺酸氨氯地平和氯沙坦钾联合治疗非杓型高血压患者清晨高血压疗效观察及安全性。方法选取本院收治的86例非杓型高血压患者,所有非杓型高血压患者的收取时间(2017年3月至2018年3月),电脑随机分为观察组一组(43例非杓型高血压患者)、对照组一组(43例非杓型高血压患者),分别实施苯磺酸氨氯地平和氯沙坦钾联合治疗以及常规治疗,将两组患者的治疗效果进行对比。结果观察组非杓型高血压患者的不良反应发生率4.65%低于对照组患者23.26%(P<0.05);经过治疗后,观察组非杓型高血压患者的日间舒张压(70.23±9.15)mm Hg和收缩压变化(130.12±6.01)mm Hg与对照组具有显著差异(P<0.05)。结论通过对非杓型高血压患者实施苯磺酸氨氯地平和氯沙坦钾联合治疗后,取得显著效果,能改善患者日间舒张压和收缩压,降低患者不良反应,促进患者康复。

Objective to analyze effect and safety of amlodipine besylate combined with losartan potassium in treatment of morning hypertension of non dipper hypertension patients. Methods choose 86 cases non dipper hypertensive patients from March 2017 to March 2018 in our hospital, divide them into observation group（43 cases non dipper hypertension patients） and control group（43 cases non-dipper hypertensive patients） with computer randomly. Treat them with amlodipine besylate combined with losartan potassium and routine treatment respectively. Compare curative effect of two groups. Results adverse reaction incidence of observation group was 4.65%, lower than 23.26% of control group,（P〈0.05）. After treatment, daytime diastolic pressure of observation group was（70.23±9.15） mm Hg and systolic pressure（130.12±6.01） mm Hg, with significant difference from control group,（P〈0.05）. Conclusion amlodipine besylate combined with losartan potassium has significant effect in treatment of non dipper hypertension patients, which can improve patient＇s daytime diastolic and systolic pressure, reduce adverse reaction and promote patient＇s recovery.