奥美拉唑和泮托拉唑在治疗高龄患者反流性食管炎中的临床疗效分析

Clinical Efficacy of Omeprazole and Pantoprazole in the Treatment of Elderly Patients with Reflux Esophagitis

目的比较分析奥美拉唑和泮托拉唑在治疗高龄反流性食管炎患者中的临床疗效。方法取80例高龄反流性食管炎患者参与此次研究,患者均于2013年至2017年10月份入院进行治疗。随机分组,观察组在一般治疗基础上口服奥美拉唑20mg,2次/d。对照组在一般治疗的基础上口服泮托拉唑40mg,2次/d。观察两组患者疗效及不良反应出现情况。结果观察组总有效率97.56%,不良反应发生率2.44%。对照组总有效率97.44%,不良反应发生率2.56%。两组总有效率、治愈率、不良反应发生率无显著差异,P>0.05。结论奥美拉唑和泮托拉唑治疗高龄患者的反流性食管炎疗效确切,在临床效果及不良反应发生上无显著统计学差异。

Objective To compare the clinical efficacy of omeprazole and pantoprazole in the treatment of elderly patients with reflux esophagitis. Methods 80 elderly patients with reflux esophagitis were enrolled in the study. All patients were admitted to hospital from 2013 to 2017 October. According to admission order were randomly divided into observation group and the control group and observation group based on the general treatment of oral omeprazole 20 rag, twice a day. The control group received pantoprazole 40rag twice a day on the basis of general treatment. The efficacy and adverse reactions of the two groups were observed. Results The total effective rate of the observation group was 97.56% and the incidence of adverse reactions was 2.44%. The total effective rate of the control group was 97.44% and the incidence of adverse reactions was 2.56%. There was no significant difference in the total effective rate, cure rate and incidence of adverse reactions between the two groups, P〉0.05. Conclusion The efficacy of omeprazole and pantoprazole for the treatment of reflux esophagitis in elderly patients is accurate, and there is no significant difference in clinical effect and adverse reaction.