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二甲双胍联合炔雌醇环丙孕酮对多囊卵巢综合征不孕症患者体内激素水平的影响 被引量:2

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摘要 目的:探讨关于二甲双胍联合炔雌醇环丙孕酮治疗多囊卵巢综合征不孕症对患者体内激素水平的影响效果,为临床提供数据参考。方法:随机选取2017年1月至2017年8月在本科接受治疗的118例多囊卵巢综合征不孕症患者为观察对象,根据随机数字法分为观察组和对照组,各59例,观察组采用二甲双胍联合炔雌醇环丙孕酮治疗,对照组单独采用炔雌醇环丙孕酮治疗,对比两组治疗效果。结果:治疗前,两组患者的FSH、LH、INS值比较,差异无统计学意义(P>0.05);治疗后,两组患者的FSH值比较,差异无统计学意义(P>0.05),观察组的LH、INS值明显低于对照组,差异有统计学意义(P <0.05);观察组排卵率为88.14%,高于对照组的72.88%,观察组的妊娠率为44.07%,高于对照组的25.42%,差异有统计学意义(P <0.05)。结论:二甲双胍联合炔雌醇环丙孕酮对多囊卵巢综合征不孕症患者体内激素水平的影响效果显著,有重要临床意义。
作者 詹芳 翟文杰
出处 《中外女性健康研究》 2018年第22期75-75,170,共2页 Women's Health Research
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  • 1张芸.子宫内膜异位症保守性手术后应用炔雌醇环丙孕酮的临床疗效观察[J].临床军医杂志,2010,38(4):603-605. 被引量:2
  • 2刘锦霞,党洁明,吴元赭,郑宁,吴效科.二甲双胍联合环丙孕酮/炔雌醇治疗多囊卵巢综合征的临床研究[J].医学研究生学报,2006,19(6):530-533. 被引量:30
  • 3DIAZ M, CHACON M R, LOPEZ-BERMEJO A, et al. Ethinyl estradiol-cyproterone acetate versus low-dose pioglitazone-flutamide-metformin for adolescent girls with androgen excess: divergent effects on CD163, TWEAK receptor, ANGPTL4, and LEPTIN expression in subcutaneous adipose tissue[J]. J Clin Endocrinol Metab, 2012, 97(10): 3630-3638.
  • 4CINAR N, HARMANCI A, BAYRAKTAR M, et al. Ethinyl estradiol-drospirenone vs ethinyl estradiol-drospirenone plus metformin in the treatment of lean women with polycystic ovary syndrome[J]. Clin Endocrinol, 2013, 78(3): 379-384.
  • 5CHRISTAKOU C, KOLLIAS A, PIPERI C, et al. The benefit-to-risk ratio of common treatments in PCOS: effect of oral contraceptives versus metformin on atherogenic markers[J]. Hormones, 2015, 13(4): 488-497.
  • 6GLINTBORG D, MUMM H, ALTINOK M L, et al. Adiponectin, interleukin-6, monocyte chemoattractant protein-1, and regional fat mass during 12-month randomized treatment with metformin and/or oral contraceptives in polycystic ovary syndrome[J]. J Endocrinol Invest, 2014, 37(8): 757-764.
  • 7GANIE M A, KHURANA M L, NISAR S, et al. Improved efficacy of low-dose spironolactone and metformin combination than either drug alone in the management of women with polycystic ovary syndrome (PCOS): a six-month, open-label randomized study[J]. J Clin Endocrinol Metab, 2013, 98(9): 3599-3607.
  • 8KAYA M G, CALAPKORUR B, KARACA Z, et al. The effects of treatment with drospirenone/ethinyl oestradiol alone or in combination with metformin on elastic properties of aorta in women with polycystic ovary syndrome[J]. Clin Endocrinol, 2012, 77(6): 885-892.
  • 9GODE F, KARAGOZ C, POSACI C, et al. Alteration of cardiovascular risk parameters in women with polycystic ovary syndrome who were prescribed to ethinyl estradiol-cyproterone acetate[J]. Arch Gynecol Obstet, 2011, 284(4): 923-929.
  • 10WILLIAMS R M, ONG K K, DUNGER D B. Polycystic ovarian syndrome during puberty and adolescence[J]. Mol Cell Endocrinol, 2013, 373(1/2): 61-67.

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