可手术胃肠道肿瘤患者血清TK1表达及其临床意义

The Serum Expression and Clinical Significance of TK1 in Preoperation in Operable Patients With Gastric and Colorectal Cancer

目的研究可手术胃癌、结直肠癌患者血清TK1表达特点及其与临床病理特征的关系。方法应用化学发光方法检测可手术65例胃癌、结直肠癌患者术前血清TK1表达情况,并分析TK1与临床特征之间的关系。结果 (1)65例患者术前血清TK1阳性6例(阳性率9.23%)。(2)SPSS Pearson相关性结果表明:血清TK1的表达男性明显为多(χ~2=4.13,P <0.05)、并且TK1表达与Her-2的表达呈正相关关系(r=0.746,P <0.05),而与年龄、T分期、分化程度、淋巴结转移、有无贫血之间均无相关关系。(3)术SPSSPearson相关性结果表明:TK1表达阳性患者的Ki-67水平高于阴性患者,差异具有统计学意义,且呈正相关性(r=0.396,P <0.01),而与Hb水平无相关性(r=-0.261 6,P> 0.05)。(4)术前TK1表达与年龄、T分期、淋巴结转移、分化程度和贫血均无关(P> 0.05)。(5)随访至2018年9月,结果为:TK1阳性死亡3/6(50.0%)、存活3/6(50.00%),TK1阴性死亡率8.47%(5/59)、存活率91.53%(54/59),两者比较,差异具有统计学意义(χ~2=6.498,P <0.01)。结论胃肠道癌症患者术前血清TK1的表达与Her-2表达和Ki-67表达有关。检测术前血清TK1对于指导合理治疗和判断患者的预后有一定意义。

Objective To study the expression of serum TK1 in patients with operable gastric cancer and colorectal cancer and its relationship with clinicopathological features. Methods The expression of TK1 in preoperative serum of 65 patients with gastric cancer and colorectal cancer was detected by chemiluminescence method. The relationship between TK1 and clinical features was analyzed. Results （1） There were 6 cases of preoperative serum TK1 positive in 65 patients （positive rate 9.23%）. （2） The results of SPSS Pearson correlation showed that the expression of serum TK1 was significantly higher in males （χ^2=4.13, P〈0.05）, and the expression of TK1 was positively correlated with the expression of Her-2 （r=0.746, P〈0.05）. There was no correlation between T stage, degree of differentiation, lymph node metastasis, and presence or absence of anemia. （3） The results of SPSS Pearson correlation showed that the Ki-67 level of patients with positive TK1 expression was signifcantly higher than that of negative patients （r=0.396, P〈0.01）, showing a positive correlation （P〈0.05）, but no correlation with Hb level （χ^2=-0.261 6, P〉0.05）. （4） Preoperative TK1 expression was not associated with age, T stage, lymph node metastasis, degree of differentiation and anemia （both P〉0.05）. （5） Follow-up to September 2018, the results were TK1 positive death rate 50.0% （3/6）, the survival rate 50.00% （3/6）, TK1 negative death rate 8.47% （5/59）, the survival rate 91.53% （54/59）, the difference was not statistically signifcant （χ^2=6.498, P〈0.01）. Conclusion The expression of serum TK1 in patients with gastrointestinal cancer is related to Her-2 expression and Ki-67 expression. Preoperative serum TK1 has a certain significance for guiding reasonable treatment and judging the prognosis of patients.