熊去氧胆酸治疗非酒精性脂肪肝的临床价值分析

Clinical Value of Ursodeoxycholic Acid in the Treatment of Nonalcoholic Fatty Liver Disease

目的探讨熊去养胆酸治疗非酒精性脂肪肝的临床价值。方法选取我院收治的120例非酒精性脂肪肝患者作为研究对象。按照入院顺序,将其分为观察组(n=60)与参考组(n=60)。观察组采用熊去氧胆酸+二甲双胍治疗,参考组采用多烯磷脂胆碱胶囊+二甲双胍治疗,比较分析两组治疗效果、肝功能、血脂指标及不良反应发生情况。结果观察组患者的治疗总有效率、生化指标等均优于参考组,差异具有统计学意义(P <0.05);观察组不良反应发生率低于参考组,差异具有统计学意义(P <0.05)。结论熊去氧胆酸治疗非酒精性脂肪肝可改善肝功能及血脂水平,提高治疗效果,且安全性较高。

Objective To explore the clinical value of ursodylcholic acid in the treatment of non-alcoholic fatty liver. Methods 120 patients with non-alcoholic fatty liver in our hospital were selected as the study objects and they were divided into observation group （n = 60） and reference group （n = 60）. The observation group was treated with metformin ursodeoxycholate, and the reference group was treated with metformin. The therapeutic effect, liver function, blood lipids and adverse reaction of the two groups were compared and analyzed. Results The total effective rate and biochemical indexes of the observation group were better than those of the reference group, and the difference was statistically significant （P 〈 0.05）. The incidence of adverse reactions in the observation group was lower than that in the reference group, and the difference was statistically signifcant （P 〈 0.05）. Conclusion The treatment of non-alcoholic fatty liver with ursodeoxycholic acid can improve the liver function and blood lipid level, improve the therapeutic effect, and have higher safety.