纤维蛋白原、血栓前体蛋白与冠心病患者冠状动脉病变程度的相关性分析

Correlation between fibrinogen,thrombus precursor protein and severity of coronary artery disease in patients with coronary heart disease

目的探讨纤维蛋白原(Fg)、血栓前体蛋白(TpP)与冠心病(CHD)患者冠脉病变程度的相关性。方法选取115例CHD患者作为观察组,并根据冠脉病变程度采用SYNTAX评分分为低危组、中危组、高危组。另选取同期入院体检的37例健康人作为对照组。比较观察组和对照组患者的一般资料,比较不同严重程度CHD患者血脂生化指标及Fg、TpP等指标,分析各生化指标与冠状动脉SYNTAX评分的关系。结果观察组和对照组患者总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、Fg、TpP比较,差异有统计学意义(P <0. 05);低危组、中危组和高危组患者TC、LDL-C、Fg、TpP比较,差异有统计学意义(P <0. 05)。Pearson相关性分析发现,Fg、Tp P、LDL-C与SYNTAX积分呈显著正相关(r=0. 559、0. 258、0. 212,P <0. 05)。结论 CHD患者血液中Fg、Tp P含量显著高于正常组,且Fg、TpP与CHD患者冠脉病变程度呈正相关。

Objective To explore the correlation between fibrinogen （Fg）, thrombus precursor protein （TpP） and severity of coronary artery disease in patients with coronary heart disease （CHD）. Methods Totally 115 CHD patients were selected as observation group, and they were divided into low risk group, middle risk group and high risk group according to severity of coronary artery disease and SYNTAX scores. Another 37 healthy people in the same period were selected as control group. The general materials were compared between the observation group and the control group, the biochemical indexes of blood lipids and the Fg, TpP levels were compared between patients with different severity of CHD, and the relationship between the biochemical indexes and theSYNTAX score were analyzed. Results There were significant differences in the levels of TC, LDL-C, Fg and TpP between the observation group and the control group （ P 〈0.05）. There were significant differences in the levels of TC, LDL-C, Fg and TpP among low risk group, middle risk group and high risk group （ P 〈0.05）. Pearson correlation analysis showed that Fg, TpP and LDL-C were positively correlated with SYNTAX score （ r =0.559, 0.258, 0.212, P 〈0.05）. Conclusion The levelsof Fg and TpP in CHD patients are significantly higher than those in normal subjects, and Fg and TpP are positively correlated with severity of coronary lesions in CHD patients.