维生素D受体与慢性阻塞性肺病易感性的关联

Correlation between vitamin D and susceptibility of chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺病(COPD)发病风险与维生素D受体(VDR)及其基因多态性的关联。方法选取并检测VDR基因FokI和Apa I位点基因型,分析其在COPD组(病例组)与健康对照组中的分布情况。结果 COPD患者VDR mRNA的表达量显著低于对照者(P <0. 01);多因素Logistic回归分析显示,Fok I点Ff基因型在病例组中的分布显著高于健康对照组(调整OR=1. 96,95%CI=1. 32～2. 92);未发现ApaI位点各基因型在对照组与病例组中存在分布差异;协方差分析结果显示,在对照组与病例组中,FokI位点不同基因型中VDR mRNA表达水平存在统计学差异(P <0. 01)。结论 VDR基因遗传变异与慢性阻塞性肺病的发病风险密切关联。

Objective To investigate the association between chronic obstructive pulmonary diseas（COPD）e and vitamin D receptor（VDR）, genetic polymorphisms. Methods The FokI and ApaI loci of all subjects were detected, and the distribution in COPD group（case group） and healthy controls. Results The expression of mRNA in VDR in COPD patients was lower than the in the control was （ P 〈0.01）. Multivariate Logistic regression analysis showed that the distribution of Ff genotype in FokI loci of the case group was significantly higher than that in the healthy controls（adjusted OR =1.96, 95%CI=1.32～2.92）. No significant difference was found in genotype distribution in ApaI genetic locus. Covariance analysis showed that the expression of mRNA in VDR in different FokI loci had significant differences（ P 〈0.01）. Conclusion Genetic variants of the VDR gene are closely associated with the risk of COPD.