阿加曲班对后循环脑梗死的临床疗效

Clinical efficacy of argatroban for posterior circulation cerebral infarction

目的探讨阿加曲班治疗后循环脑梗死的临床疗效。方法将76例急性后循环脑梗死患者随机分为观察组(阿加曲班治疗组)、对照组(常规治疗组),各38例。比较2组治疗前后神经功能缺损评分、Barthel指数及血液流变学指标,观察组在治疗期间进行凝血功能、血栓弹力图检测,探讨阿加曲班治疗后循环脑梗死的临床效果。结果阿加曲班治疗组的神经功能缺损评分与Barthel指数显著优于对照组(P <0. 05)。结论阿加曲班治疗后循环脑梗死的疗效确切。

Objective To investigate the clinical efficacy of argatroban in the treatment of posterior circulation cerebral infarction. Methods A total of 76 patients with posterior circulation cerebral infarction were randomly divided into observation group and control group, with 38 cases in each group. The nerve function defect grade, Barthel index and hemorheological indexes were measured before and after treatment in two groups. Coagulation function and thromboelastograph in the observation group were detected during the treatment. And the clinical effect of argatroban in the treatment of posterior circulation cerebral infarction was discussed. Results After treatment, the nerve function defect scores and Barthel index in the observation group were better than that in the control group（ P 〈0.05）. Conclusion Argatroban has better efficacy in treating posterior circulation cerebral infarction.