摘要
The spontaneous oscillatory contraction（SPOC） of myofibrils is the essential property inherent to the contractile system of muscle. Muscle contraction results from cyclic interactions between actin filament and myosin II which is a dimeric motor protein with two heads. Taking the two heads of myosin II as an indivisible element and considering the effects of cooperative behavior between the two heads on rate constants in the mechanochemical cycle, the present work proposes the tenstate mechanochemical cycle model for myosin II dimer. The simulations of this model show that the proportion of myosin II in different states periodically changes with time, which results in the sustained oscillations of contractive tension, and serves as the primary factor for SPOC. The good fit of this model to experimental results suggests that the cooperative interaction between the two heads of myosin II dimer may be one of the underlying mechanisms for muscle contraction.
The spontaneous oscillatory contraction（SPOC） of myofibrils is the essential property inherent to the contractile system of muscle. Muscle contraction results from cyclic interactions between actin filament and myosin II which is a dimeric motor protein with two heads. Taking the two heads of myosin II as an indivisible element and considering the effects of cooperative behavior between the two heads on rate constants in the mechanochemical cycle, the present work proposes the tenstate mechanochemical cycle model for myosin II dimer. The simulations of this model show that the proportion of myosin II in different states periodically changes with time, which results in the sustained oscillations of contractive tension, and serves as the primary factor for SPOC. The good fit of this model to experimental results suggests that the cooperative interaction between the two heads of myosin II dimer may be one of the underlying mechanisms for muscle contraction.
作者
Wei Sun
Xiao-Yang Zhao
Jun-Ping Zhang
Tala
Wei-Sheng Guo
孙伟;赵晓阳;张俊萍;塔拉;郭维生(School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China;Department of Resource Engineering, Ordos Vocational College, Ordos 017000, China;Department of Statistics and Mathematics, Inner Mongolia University of Finance and Economics, Hohhot 010070;Inner Mongolia Vocational College of Chemical Engineering, Hohhot 010070, China)
基金
Project supported by Research Program of Science and Technology at Universities of Inner Mongolia Autonomous Region,China(Grant Nos.NJZY16493and NJZC17458)
