β-catenin、c-myc和E-cadherin在结直肠癌中的表达及意义

Expression of β-catenin、c-myc and E-cadherin in colorectal cancer

目的探讨β-catenin、c-myc和E-cadherin在结直肠癌中的表达及其与临床意义。方法通过免疫组化检测三种蛋白在结直肠癌组织及正常组织中的表达,分析三种蛋白的表达与临床资料之间的关系。结果相对于正常结直肠组织,结直肠癌组织中的β-catenin、c-myc蛋白表达的阳性率明显升高,而E-cadherin蛋白表达明显下降。三者蛋白的异常表达均与淋巴结转移相关,β-catenin、c-myc表达与细胞分化呈正相关,E-cadherin表达与其呈负相关。结论三种蛋白在结直肠癌组织的异常表达,其表达与侵袭和转移相关,从而对评估结直肠癌bianzhibin的预后有重要临床意义。

Objective To explore the value ofβ-catenin,c-myc and E-cadherin expression in colorectal cancer in order to find its clinical significance.Methods Three kinds of protein expression were detected by immunohistochemical in colorectal cancer tissues and normal tissues.The relationship between three kinds of protein expression and the clinical data were analyzed.Results In comparing with normal colorectal tissues,Expression ofβ-catenin,c-myc protein in colorectal cancer tissue increased significantly,expression of E-cadherin protein decreased obviously.Expression of three protein was abnormal,which were associated with lymph node metastasis.Expression ofβ-catenin and c-myc were positively related with cell differentiation,Expression of E-cadherin was negatively related to cell differentiation.Conclusion Expression of three kinds of protein were abnormal in colorectal cancer tissue,which is associated with invasion and metastasis.They have important clinical significance to evaluate the prognosis of colorectal cancer.