丁苯酞注射液联合经颅磁刺激治疗急性脑梗死后运动性失语观察

Effects of Butylphthalide Injection Combined with Transcranial Magnetic Stimulation on Motor Aphasia in Patients with Acute Cerebral Infarction

目的:观察丁苯酞注射液联合经颅磁刺激(TMS)治疗急性脑梗死后运动性失语症的疗效。方法:92例急性脑梗死后运动性失语患者随机分为对照组(n=46)和观察组(n=46)。2组患者均给予常规药物治疗及言语训练,在此基础上对照组实施TMS治疗;观察组实施丁苯酞注射液联合TMS治疗。比较两组治疗前后美国国立卫生研究院卒中量表(NIHSS)、失语指数(AQ)、中国式功能性语言沟通能力检查法(CFCP)评分以及西语失语成套测验(WBC)评分和失语严重程度。根据语言功能提高百分率和交流障碍好转程度进行疗效评定。结果:治疗后两组NIHSS、AQ及CFCP评分均有明显提高,流利性、听理解、复述、命名等项目得分均有显著提高,失语程度明显改善(P <0. 05),且治疗后观察组上述指标均明显优于对照组(P <0. 05)。观察组治疗后总有效率为85. 2%,明显高于对照组的65. 8%(P <0. 05)。结论:丁苯酞注射液联合TMS治疗对于脑梗死后运动性失语具有较好的疗效。

Objective： To investigate the clinical effects of butylphthalide injection combined with transcranial magnetic stimulation （TMS） on motor aphasia in patients with acute cerebral infarction. Methods： Totally 92 cases of acute cerebral infarction patients with motor aphasia meeting the inclusion criteria were randomly divided into the control group （n =46） and the observation group （n =46）. The patients in the control group were treated with TMS on the basis of the conventional drugs and language rehabilitation training, and those in the observation group were treated with butylphthalide injection on the basis of the control group. NIHSS scores, aphasia quo- tient （AQ） scores, CFCP scores, WBC scores and severity of aphasia before and after the treatment were compared between the groups. The curative effects were evaluated by language features increased percentage and communication barriers improvement. Resuits： NIHSS scores, AQ scores and CFCP scores after the treatment were improved significantly in the two groups, and spontaneous speech, listening comprehension, retelling and naming were improved significantly as well. The improvement of the observation group was more significant than that of the control group （ P 〈 0.05 ） after the treatment. After the treatment, the total effective rate in the ob- servation group was 85.2%, which was significantly higher than that （65.8%） in the control group （P 〈 0.05 ）. Conclusion： Butylphthalide injection combined with TMS has better effect on motor aphasia after acute cerebral infarction.