尿微量蛋白联合血凝检测诊断冠心病价值分析

Analysis of the value of urinary microprotein combined with hemagglutination in the diagnosis of coronary heart disease

目的：探讨尿微量蛋白联合血凝检测诊断冠心病的价值;方法：选取2018年1月～2018年4月本院心血管内科收治的90例冠状动脉粥样硬化心脏病患者,其中急性心肌梗死28例,不稳定型心绞痛32例,稳定型心绞痛30例,同时选取健康体检中心30例身体健康者作为对照组,比较四组受试对象尿微量白蛋白及血浆纤维蛋白原含量,分析受试对象尿微量白蛋白和血浆纤维蛋白原含量相关性;结果：四组受试对象尿微量白蛋白及血浆纤维蛋白原含量差异具有统计学意义（P〈0.05）,进一步两两比较显示：急性心肌梗死组患者尿微量白蛋白、 血浆纤维蛋白原含量最高,不稳定型心绞痛组、 稳定型心绞痛组次之,含量最低的为对照组,差异均具有统计学意义（P〈0.05）,尿微量白蛋白和血浆纤维蛋白原含量相关性分析显示尿微量白蛋白和血浆纤维蛋白原含量呈现正相关（r=0.771,P〈0.001）,等级相关显示：尿微量白蛋白和血浆纤维蛋白原含量与稳定性、 不稳定性心绞痛、 急性心肌梗死组的顺序逐渐增高,两个指标均与冠心病的分级呈良好的等级相关关系（r1=0.858,P1〈0.05,r2=0.871,P2〈0.05）;结论：尿微量蛋白联合血凝检测应用于诊断冠心病,在检测结果客观、 客观的情况下,可以客观反映患者冠心病实际病情,有助于及早诊断冠心病和给予有效的治疗,改善患者的预后,值得推广.

Objective： To explore the value of urinary microprotein combined with hemagglutination in coronary heart disease. Methods： A total of 90 patients with coronary atherosclerotic heart disease admitted to our department of cardiovascular medicine from January 2018 to April 2018 were selected. Among them, 28 cases were acute myocardial infarction, 32 cases were unstable angina pectoris, and 30 cases were stable angina pectoris, in parallel, 30 healthy people from healthy medical centers were selected as the control group. The urinary microalbumin and serum fibrinogen levels were compared among the four groups of subjects and the correlation between urine microalbumin and serum fibrinogen levels was analyze＆ Results： There were significant differences in urinary microalbumin and serum fibrinogen levels among the four groups （P〈0.05）. Further comparisons showed that the levels of urine microalbumin and serum fibrinogen were highest in patients with acute myocardial infarction. The unstable angina group and the stable angina group were followed, the lowest was the control group, and the difference was statistically significant （P〈0.05） . The correlation analysis between urine microalbumin and serum fibrinogen levels showed that： There was a positive correlation between serum albumin and serum fibrinogen levels （r=0.771, P〈 0.001）. Grade correlation showed： urine microalbumin and serum fibrinogen levels and stability, unstable angina, and sequence of acute myocardial infarction Gradually increased, both indicators showed a good hierarchical correlation with coronary heart disease grading （rl= 0.858, P~〈0.05, ra=0.871, P2〈0.05）. Conclusion： Urine trace protein combined with hemagglutination test can be used to diagnose coronary heart disease. It can objectively reflect the actual condition of patients with coronary heart disease under the objective and objective test results. It can help early diagnosis of coronary heart disease and provide effective treatment to improve the conditions of prognosis. The prognosis is recommended for clinical promotion.