急性缺血性卒中与血糖波动关系的研究进展

Progress in Relationship between Acute Ischemic Stroke and Glycemic Fluctuation

30%～40%急性期脑梗死患者存在应激性高血糖现象,并且与患者尤其是非糖尿病患者的不良预后相关。强化降糖并未改善这类患者的预后,反而会增加低血糖发生风险。血糖波动是指血糖在波峰波谷间的波动状态,其可以通过氧化应激和炎症反应导致血管内皮细胞凋亡,而急性期脑梗死患者出现应激性高血糖可能是血糖波动的一种表象,未来需要更深入的研究。

Stress hyperglycemia can occur in 30%-40% of patients with acute ischemic stroke, which is associated with poor prognosis, especially those without diabetes. Intensive hyperglycemia management didn＇t improve the outcome of such patients, and increased the risk of hypoglycemia instead. Glycemic fluctuation can lead to vascular endothelial cell apoptosis through oxidative stress and inflammatory reaction. Stress hyperglycemia occurring soon after acute ischemic stroke may be just an interesting and special phenomenon of glycemic fluctuation, which still needs further research in the future.