银屑病的甲基化相关研究进展

The methylation related research progress in psoriasis

银屑病是一种由多种因素相互作用而导致的多基因遗传病,表观遗传学是在基因表达水平发生的不涉及DNA序列改变的可遗传的变化,主要机制包括DNA甲基化、组蛋白修饰及非编码RNA调控。近年来许多证据表明银屑病的发病与表观遗传学有一定相关性,其中关于甲基化的研究较多,该文就银屑病的表观遗传学研究中甲基化方面进展进行综述。

Psoriasis is a multi-gene genetic disease caused by the interaction of many factors. Epigenetics is one kind of genetic changes that does not involve DNA sequence changes at the level of gene expression. The main mechanisms include DNA methylation, histone modification and noncoding RNA regulation. In recent years, many evidences had shown that the pathogenesis of psoriasis is related to epigenetics. There were many studies about methylation, in this paper the advances in epigenetic changes about methylation in psoriasis were reviewed.