康复新液联合西洛他唑治疗糖尿病足的疗效观察

Clinical study on Kangfuxin Liquid combined with cilostazol in treatment of diabetic foot

目的探讨康复新液联合西洛他唑联合治疗糖尿病足的有效性和安全性。方法选取许昌市中心医院2013年7月—2017年7月收治的糖尿病足患者101例,随机分成对照组(50例)和治疗组(51例)。对照组口服西洛他唑片,2片/次,2次/d;治疗组患者在对照组的基础上外敷康复新液,取50 mL浸润无菌纱布敷于患者足部,1次/d。两组患者连续治疗2周。观察两组患者临床疗效,同时比较治疗前后两组患者创伤面收缩率和足部溃疡愈合时间及周围神经传导速度。结果治疗后,对照组和治疗组临床有效率分别为82.00%和96.08%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者创伤面积收缩率显著高于对照组,足部溃疡愈合时间显著短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者尺神经、胫神经和腓神经的传导速度均显著加快,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组患者周围神经传导速度明显快于对照组,两组比较差异具有统计学意义(P<0.05)。结论康复新液联合西洛他唑治疗糖尿病足疗效好、安全性高,并且能够加快溃疡面愈合,具有一定的临床推广应用价值。

Objective To exlpore the clinical efficacy and safety of Kangfuxin Liquid combined with cilostazol in treatment of diabetic foot. Methods Patients（101 cases） with diabetic foot in Xuchang Central Hospital from July 2013 to July 2017 were randomly divided into control（50 cases） and treatment（51 cases） groups. Patients in the control group were po administered with Cilostazol Tablets, 2 tablets/time, twice daily. Patients in the treatment group were external administered with Kangfuxin Liquid on the basis of the control group, 50 mL infiltrated sterile gauze and applied to the foot, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the wound area shrinkage rate, foot ulcer healing time, and the conduction velocity of peripheral nerve in two groups before and after treatment was compared. Results After treatment, the clinical efficacy in the control and treatment groups was 82.00% and 96.08% respectively, and there were differences between two groups（P 〈 0.05）. After treatment, the wound area shrinkage rate in the treatment group was significantly higher than that in the control group, and foot ulcer healing time of the treatment group was significantly shorter, with significant difference between two groups（P 〈 0.05）. After treatment, the conduction velocity of ulnar nerve, tibial nerve, and peroneal nerve in two groups was significantly increased, and the difference was statistically significant in the same group（P 〈 0.05）, and the conduction velocity of peripheral nerve in the treatment group after treatment was significantly faster than those in the control group, with significant difference between two groups（P 〈 0.05）. Conclusion Kangfuxin Liquid combined with cilostazol in treatment of diabetic foot has good curative effect and high safety, can accelerate ulcer healing, which has a certain clinical application value.