健脾养阴袋泡剂干预2型糖尿病前期临床研究

Clinical Study on Intervention of Jianpi Yangyin Teabag for Type 2 Prediabetes

目的:观察健脾养阴袋泡剂干预气阴两虚型2型糖尿病前期患者的临床疗效。方法:选取150例气阴两虚型2型糖尿病前期患者,随机分为单纯对照组、西药对照组、观察组,各50例,单纯对照组给以单纯生活方式干预,西药对照组服用二甲双胍片+生活方式干预,观察组给予健脾养阴袋泡剂联合生活方式干预。比较3组干预后血糖、胰岛功能和代谢性指标的变化。结果:干预前,3组空腹血糖(FBG)、餐后2h血糖(P2hBG)、糖化血红蛋白(HbA1c)、胰岛β细胞功能(HOMA-β)、胰岛素抵抗指数(HOMA-IR)、血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、血清尿酸(SUA)比较,差异均无统计学意义(P>0.05)。干预后,3组FBG、P2hBG及HbA1c分别较干预前下降,HOMA-IR均低于干预前,HOMA-β均高于干预前,差异均有统计学意义(P <0.05);观察组FBG、P2hBG、HbA1c高于西药对照组,P2hBG、HbA1c、HOMA-IR低于单纯对照组,HOMA-β高于单纯对照组,差异均有统计学意义(P <0.05)。干预后,观察组、西药对照组TC较治疗前下降,且均低于单纯对照组,差异均有统计学意义(P <0.05)。结论:健脾养阴袋泡剂能有效降低气阴两虚证糖尿病前期患者的血糖水平,可以缓解机体的胰岛素抵抗状态,提高β细胞功能,恢复组织对胰岛素的敏感性,对代谢性指标有一定的调节作用。

Objective： To observe the clinical effect of the intervention of Jianpi Yangyin teabag for type 2 prediabetes of qi-yin deficiency type. Methods. Selected 150 cases of patients with type 2 prediabetes of qi-yin deficiency type and divided them into the simple control group, the western medicine control group and the observation group randomly, 50 cases in each group. The simple control group was given the intervention of simple lifestyle, the western medicine control group was given the intervention of metformin tablets plus lifestyle, and the observation group was given the intervention of Jianpi Yangyin teabag combined with lifestyle. Compared the changes of blood glucose, islet function and metabolic index in the three groups after intervention. Results： Before intervention, compared the levels of fasting blood glucose（FBG）, postprandial 2h blood glucose（P2hBG）, glycosylated hemoglobin（HbAlc）, islet β-cell function （HOMA-β）, insulin resistance index （HOMA-IR）, serum total cholesterol（TC）, low density lipoprotein cholesterol（LDL-C） and serum uric acid （SUA） in the three groups, there was no significance in difference（P 〉 0.05）. After intervention, levels of FBG, P2hBG and HbAlc in the three groups were decreased when compared with those before intervention; the level of HOMA-IR was lower than that before intervention and the level of HOMA-β was higher than that before intervention, differences being significant （P 〈 0.05）. Levels of FBG, P2hBG and HbAlc in the observation group were higher than those in the western medicine control group; levels of P2hBG and HbAlc as well as HQMA-IR in the observation group were lower than those in the simple control group and HOMA-β in the observation group was higher than that in the simple control group, differences being significant（P 〈 0.05）. After intervention, levels of TC in the observation group and the western medicine control group were decreased when compared with those before treatment, and were Jower than that in the simple control group, differences being significant （P〈0.05）. Conclusion： The therapy of Jianpi Yangyin teabag for type 2 prediabetes of qi-yin deficiency type can effectively decrease the level of blood glucose of patients, relieve the insulin resistant state of body, improve β-cell function and recover the sensitivity of tissue to insulin, which has regulating effect on the metabolic index.