藤黄健骨胶囊联合常规疗法治疗骨性关节炎疗效观察

Clinical Observation of Tenghuang Jian'gu Capsules Combined with Routine Therapy for Osteoarthritis

目的:观察藤黄健骨胶囊联合常规疗法治疗骨性关节炎(OA)患者的临床疗效。方法:将90例(90个关节) OA患者随机分为2组各45例(各45个关节),对照组常规予关节腔内玻璃酸钠溶液注射,双氯芬酸二乙胺乳胶剂外用治疗;观察组在常规治疗的基础上加用藤黄健骨胶囊治疗,治疗8周后观察比较2组患者临床疗效及治疗前后临床症状改善情况,不良反应发生情况。结果:临床总有效率观察组为95.56%,对照组为75.56%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组患者疼痛程度、肿胀程度和关节功能评分及总分均较治疗前显著下降(P <0.05),且观察组上述评分降低较对照组更显著(P <0.05)。不良反应发生率观察组为6.67%,对照组为4.44%,2组比较,差异无统计学意义(P> 0.05)。结论:常规疗法联合藤黄健骨胶囊治疗OA可提高疗效,改善患者临床症状,且不增加不良反应。

Objective： To observe the clinical effect of Tenghuang Jian＇gu capsules combined with routine therapy for patients with osteoarthritis （OA）. Methods- Divided 90 cases （90 nodes） of patients with OA into two groups randomly, 45 cases in each group. The control group was injected with sodium hyaluronate solution and diclofenac diethylamine emulgel for external treatment, while the observation group was treated with Tenghuang Jian＇gu capsules on the basis of routine therapy. After 8 weeks of treatment, observed and compared the clinical effect and the improvement of clinical symptoms and incidence of adverse reactions of patients in the two groups before and after treatment. Results： The total clinical effective rate was 95.56% in the observation group and 75.56% in the control group, compared the two groups, difference being significant （P 〈 0.05）. After treatment, the degrees of pain, degrees of swelling, joint function scores and total scores in the two groups were significantly decreased when compared with those before treatment （P 〈 0.05）, and the decrease of the scores mentioned above in the observation group were obviously lower than those in the control group （P 〈 0.05）. The incidence of adverse reactions was 6.67% in the observation group and 4.44% in the control group, and there was no significant difference being found in the comparison of the two groups （P 〉 0.05）. Conclusion. Routine therapy combined with Tenghuang Jian＇gu capsules can promote the clinical effect and improve the clinical symptoms, and does not increase adverse reactions.