口炎清颗粒治疗复发性口腔溃疡疗效观察

Clinical Observation of Kouyanqing Granules for Recurrent Oral Ulcer

目的:观察口炎清颗粒对复发性口腔溃疡患者的临床疗效及对患者口腔疼痛的影响。方法:将复发性口腔溃疡患者73例按入院顺序随机分为对照组36例、研究组37例,对照组给予常规西医治疗,研究组在对照组的基础上联合口炎清颗粒治疗,1周为1疗程,2组均连续治疗2疗程。治疗后统计2组临床疗效,评估并比较2组治疗前后主要临床症候积分、口腔疼痛情况,治疗后随访12个月以比较2组复发情况。结果:治疗2周后,研究组临床总有效率高达94.59%,高于对照组的72.22%(χ2=6.649,P <0.05)。治疗2周后,2组患者溃疡面积、溃疡数目、充血、水肿、渗出及灼烧感等证候积分与治疗前比较均降低(P <0.01),且研究组低于对照组(P <0.01)。与治疗前比较,治疗后2组患者口腔VAS评分均呈逐渐降低趋势(P <0.01),治疗1周后、治疗2周后、治疗1月后研究组口腔VAS评分均低于对照组(P <0.01)。与治疗前比较,治疗后2组溃疡数目先降低后升高(P <0.01),但治疗6、12月后研究组溃疡数目均较对照组降低(P <0.01),研究组溃疡发作总间歇时间较对照组显著延长(P <0.01)。结论:口炎清颗粒可有效改善复发性口腔炎患者临床症状,缓解患者口腔疼痛,并可在一定程度上预防复发,疗效显著优于常规西医治疗。

Objective.. To observe the clinical effect of Kouyanqing granules for patients with recurrent oral ulcer, and its effect on oral pain. Methods. Divided 73 cases of patients with recurrent oral ulcer into two groups randomly according to the hospitalization order, 36 cases in the control group and 37 cases in the research group. The control group was given the routine western medicine therapy, while the research group was additionally given Kouyanqing granules. The treatment for both groups lasted for two courses, one week as one course. After treatment, statistically analyzed the clinical effect in both groups, evaluated and compared scores of main clinical symptoms and the status of oral pain in both groups before and after treatment, and compared the recurrence in both groups by follow-ups for 12 months. Results： After treatment for two weeks, the total effective rate was 94.59% in the research group, being higher than 72.22% in the control group（χ^2= 6.649, P 〈 0.05）. After treatment for two weeks, symptom scores of the area of ulcer, the number of ulcer, hyperemia, edema, effusion and burning sensation in both groups were lower than those before treatment（P 〈 0.01）, and the symptom scores in the research group were lower than those in the control group（P 〈 0.01）. Comparing with those before treatment, scores of VAS in the oral cavity of patients in both groups after treatment showed a trend of progressive decrease（P 〈 0.01）, and after treatment for one week, two weeks and one month, scores of VAS in the oral cavity of the research group were lower than those in the control group respectively（P 〈 0.01）. Comparing with those before treatment, the number of ulcer in both groups after treatment was firstly decreased and then increased（P 〈 0.01）, but after treatment for 6 and 12 months, the number of ulcer in the research group was lower than that in the control group（P 〈 0.01）, and the total interval time of ulcer occurrence in the research group was significantly prolonged when comparing with the control group（P 〈 0.01）. Conclusion： Kouyanqing granules can effectively improve the clinical symptoms of patients with recurrent oral ulcer, alleviate oral pain and prevent the recurrence, of which the clinical effect is significantly better than the routine western medicine therapy.