中医药治疗小儿咳嗽变异性哮喘用药规律研究

Research on Administration Rule of Chinese Medicine for Children with Cough Variant Astbma

目的:分析探讨中医药治疗小儿咳嗽变异性哮喘(Cough Variant Asthma,CVA)的用药规律。方法:通过中国知网、维普、万方数据库收集2010年1月—2018年1月中医药治疗CVA的文献,筛选出数据完整,疗效确切的处方,并基于关联规则算法和复杂系统熵聚类,利用中医传承辅助平台V2.5数据挖掘,分析处方中各种药物的性味归经、使用频次以及药物之间的关联规则。结果:CVA在使用中药治疗时常用的药物以归肺、脾、肝经的止咳平喘药、清热化痰药及发散风热药为主,性多温、寒、平,味苦、甘、辛。其中核心药物有杏仁、地龙、蝉蜕、僵蚕、桔梗、五味子、紫菀、陈皮、黄芩、甘草、炙麻黄、前胡等。结论:CVA治疗的药物以止咳平喘药、清热化痰药及发散风热药为主,该研究结果对治疗CVA的组方用药规律具有一定的指导意义和参考价值。

Objective： To analyze and discuss the administration rule of Chinese medicine for children with cough variant astbma（CVA）. Methods： Collected the literature on the treatment of children with CVA in Chinese medicine from January 2010 to January2018 through China knowledge network, Wanfang and VIP database and selected the prescriptions with complete data and exact curative effect. Applied the Chinese medicine inheritance platform V2.5 to do data mining,and analyzed character and taste,frequency of use and the association rules of various Chinese herbs in the prescriptions based on the association rule algorithm and entropy clustering of complex system. Results：In the treatment of Chinese medicine for children with CVA,the commonly used herbs which were attributed to lung, spleen and liver meridians were mainly those relieving cough and subduing asthma, those clearing heat and resolving phlegm and those dispersing wind and heat. These herbs have main characters of warm,neutral mild and cold and main tastes of bitter, sweet and pungent. Key herbs among those were almond, lumbricus, periostracum cicadae, muscardine silkworm,balloonflower, schisandra chinensis, aster, dried tangerine peel, scutellaria, glycyrrhiza, honey-fried herba ephedrae and radix peucedani. Conclusion：The commonly used Chinese herbs in treating children with CVA are mainly based on those relieving cough and subduing asthma, those clearing heat and resolving phlegm and those dispersing wind and heat. The result of this study has certain guiding significance and reference value for the administration rule of composing prescriptions in treating children with CVA.