长期服用中药汤剂或西药患者肝肾超声检查影像变化的研究

Research on Ultrasonographic Imaging Changes in Liver and Kidney of Patients with the Long-term Administration of Chinese Herbal Decoction or Western Medicine

目的:观察长期服用中药汤剂或西药对患者肝脏、肾脏超声检查影像变化的影响。方法:回顾性研究6 5例患者,根据服用药物的不同分为2组,研究组34例服用中药汤剂,对照组31例服用西药,观察比较2组患者服药前与服药6月后肝脏、肾脏超声检查影像的变化。结果:用药6月后,研究组肝脏、肾脏内部回声改变人数均多于用药前,肾主动脉收缩期峰值流速(PSV)、舒张末期流速(EDV)均低于用药前,差异均有统计学意义(P<0.01,P<0.05);对照组服药前后肝脏超声检查结果异常的情况无明显变化(P>0.05),肾主动脉EDV低于用药前,内部回声改变人数多于用药前,差异均有统计学意义(P<0.05)。研究组肝脏出现改变和肝、肾均出现改变的人数均多于对照组(P<0.05,P<0.01)。结论:长期服用中药汤剂与西药均会对患者的肝脏和肾脏造成一定的损伤,在临床上要注意对患者的肝肾功能进行监测,以减少不良事件的发生。

Objective： To observe the effect of the long-term administration of Chinese herbal decoction and western medicine on ultrasonographic imaging changes in liver and kidney of patients. Methods：Conducted a retrospective study of 65 cases of patients,and divided them into two groups according to the medicine they took. 34 cases in the research group received Chinese herbal decoction,while 31 cases in the control group received western medicine. Observed and compared the ultrasonographic imaging changes in liver and kidney of patients in both groups before and after 6 months administration. Results：After administration for 6 months,the number of patients with changes of the internal echo in liver and kidney in the research group was larger than that before administration, and peak systolic velocity（PSV） and end diastolic velocity（EDV） in aorta ascendens were both lower than those before administration,differences being significant（P〈0.0 1, P〈0.05）. There was no significant difference being found in the number of patients with abnormal ultrasonographic results in the control group before and after administration（P〉0.05）, EDV was lower than that before administration, and the number of patients with changes of the internal echo was larger than that before administration, differences being significant（P〈0.05）. The numbers of patients with changes in liver and in both liver and kidney in the research group were larger than those in the control group respectively（P〈0.05,P〈0.01）. Conclusion：The long-term administration of Chinese herbal decoction and western medicine will both cause certain damage to the liver and the kidney of patients. Therefore,the hepatic and renal function should be monitored clinically so as to reduce the occurrence of adverse events.