侯氏黑散加减方治疗经期头痛临床研究

Clinical Study of the Modified Prescription of Hou's Black Powder for Menstrual Headache

目的:探讨侯氏黑散加减方治疗经期头痛的临床疗效及对病人治疗前后头部疼痛评级指数(PRI评分)的影响。方法:将126例经期头痛患者按就诊顺序随机分为中药组与西药组各6 3例,西药组给予口服镇痛药及相应的对症治疗,中药组给予口服侯氏黑散加减方进行治疗。观察2组临床疗效及PRI评分、视觉模拟疼痛评分(VAS评分)。结果:总有效率中药组为9 5.24%,西药组为6 5.08%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组PRI评分、VAS评分、头痛发作次数、头痛发作持续时间、血清内皮素-1(E T-1)和超敏C-反应蛋白(hs-CRP)水平比较,差异均无统计学意义(P>0.05)。与同组治疗前比较,第3个疗程后2组PRI评分、VAS评分、头痛发作次数、头痛发作持续时间、血清E T-1和hs-CRP水平显著降低,差异均有统计学意义(P<0.05)。与同期西药组比较,中药组第1、2、3个疗程后PRI评分、VAS评分、头痛发作次数降低,第2、3个疗程后头痛发作持续时间较短,血清E T-1和hs-CRP水平较低,差异均有统计学意义(P<0.05)。结论:采用侯氏黑散加减方治疗经期头痛的临床疗效显著,且能够有效降低病人头痛PRI评分指数。

Objective：To discuss the clinical effect of the modified prescription of Hou＇s black powder for menstrual headache and the effect on the pain rating index（PRI） of head before and after treatment. Methods： Divided 126 cases of patients with menstrual headache into the Chinese medicine group and the western medicine group according to the order of visits randomly,63 cases in each group. The western medicine group was given analgesics orally and some corresponding symptomatic treatment, while the Chinese medicine group was given the modified prescription of Hou＇s black powder orally. Observed the clinical effect,the PRI scores of head and the visual analogue scale（VAS） scores in the two groups. Results： The total effective rate was 95.24% in the Chinese medicine group and 65.08% in the western medicine group, difference being significant（P〈0.05）. Before treatment, there were no significant differences being found between the comparisons of PRI scores,VAS scores,times of headache attack,duration of headache attacks and levels of serum ET-1 and hs-CRP in the two groups（P〈0.05）. Compared with the same group before treatment,the PRI scores,VAS scores, times of headache attack, duration of headache attacks and levels of serum ET-1 and hs-CRP in the two groups were significantly reduced after the third course of treatment, differences being significant（P〈0.05）. Compared with the western medicine group in the same period,the PRI scores,VAS scores and times of headache attack in the Chinese medicine group were all decreased after the first,second,and third course of treatment,and the duration of headache attacks was shorter after the second and third course of treatment,and the levels of serum ET-1 and hs-CRP were lower,differences being significant（P〈0.05）. Conclusion：The clinical application of the modified prescription of Hou＇s black powder for menstrual headache has a significant effect and can effectively reduce the PRI score of head.