大黄芒硝外敷治疗妇科恶性肿瘤患者淋巴结切除术后淋巴囊肿临床研究

Clinical Study on External Application of Rhubarb and Mirabilite for Lymphocyst in Patients with Gynecologic Malignant Tumor After Lymphadenectomy

目的:观察大黄芒硝外敷在妇科恶性肿瘤患者淋巴结切除术后淋巴囊肿中的治疗效果及安全性。方法:选取82例淋巴结切除术后发生淋巴囊肿的妇科恶性肿瘤患者,随机分为对照组与研究组各41例。对照组采取超声介入治疗,术后采取常规预防感染干预,研究组在对照组基础上采取大黄芒硝外敷,持续治疗14天。疗程结束后统计2组临床疗效,记录患者的总置管时间、囊肿消退时间、盆腔积液量、不良反应发生率,并于治疗后进行随访,统计2组淋巴囊肿复发率。结果:研究组总有效率95.12%,对照组总有效率80.49%,2组比较,差异有统计学意义(P<0.05)。治疗后,研究组总置管时间、囊肿消退时间均短于对照组,盆腔积液量少于对照组,差异均有统计学意义(P<0.01)。研究组不良反应发生率9.76%,对照组不良反应发生率4.88%,2组比较,差异无统计学意义(P>0.05)。治疗后3月、6月,研究组淋巴囊肿复发率分别为0和2.44%,对照组淋巴囊肿复发率分别为分别为4.88%和7.32%,组间比较均无明显差异(P>0.05)。结论:常规治疗基础上采取大黄芒硝外敷对淋巴结切除术后发生淋巴囊肿的妇科恶性肿瘤患者实施干预,可有效缩短囊肿消退时间及置管时间,减少盆腔积液量,且不良反应发生率较低,还可减少淋巴囊肿复发,利于改善预后。

Objective：To observe the curative effect and safety of the external application of rhubarb and mirabilite for lymphocyst in patients with gynecologic malignant tumor after lymphadenectomy. Methods：Selected 82 cases of patients with gynecologic malignant tumor in whom lymphocyst occurred after lymphadenectomy,and divided them into the control group and the study group randomly,41 cases in each group. The control group received interventional ultrasound treatment and was given routine anti-infection intervention after operation,while the study group was additionally treated with external application of rhubarb and mirabilite based on the treatment of the control group. The treatment of the two groups lasted for 14 days. After treatment,evaluated the clinical effect of the two groups and recorded the total tube-detaining time,cyst-extinction time,volume of pelvic effusion and incidence of adverse reactions of patients.Moreover,followed up patients after treatment and calculated the recurrence rate of lymphocyst. Results： The total effective rate was95.12% in the study group and was 80.49% in the control group,the difference being significant（P〈0.05）. After treatment,the total tube-detaining time and cyst-extinction time in the study group were shorter than those in the control group and the volume of pelvic effusion was less than that in the control group,differences being significant（P〈0.01）. The incidence of adverse reactions in the study group was 9.76% and was 4.88% in the control group,there being no significance in the difference（P〈0.05）. After treatment of three and six months,the recurrence rates of lymphocyst in the study group were 0 and 2.44% respectively,and those in the control group were 4.88% and 7.32% respectively, there being no significance in the difference（P〈0.05）. Conclusion： Based on the routine treatment, the additional intervention of external application of rhubarb and mirabilite for lymphocyst in patients with gynecologic malignant tumor after lymphadenectomy can effectively shorten the cyst-extinction time and tube-detaining time,reduce the volume of pelvic effusion,decrease the recurrence of lymphocyst with low incidence of adverse reactions,which is beneficial to the improvement of the prognosis.