糖皮质激素联合特布他林治疗慢性阻塞性肺疾病急性加重期的疗效分析

Effect analysis of Glucocorticoid combined with Terbutaline on acute exacerbation of chronic obstructive pulmonary disease

目的分析糖皮质激素联合特布他林治疗慢性阻塞性肺疾病(慢阻肺)急性加重期的临床疗效。方法 120例慢阻肺急性加重期患者,依据入院的先后顺序分为对照组和研究组,各60例。对照组给予特布他林治疗,研究组给予特布他林联合糖皮质激素治疗,比较两组治疗前后肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、肺活量(VC)及最大呼气流量(PEF)]。结果治疗前,两组患者的FEV1、FVC、VC及PEF比较差异无统计学意义(P>0.05)。治疗后,研究组FEV1、FVC、VC、PEF分别为(2.75±0.59)L、(3.26±0.82)L、(2.91±0.84)L、(257.7±35.4)L/min,对照组分别为(2.33±0.61)L、(2.85±0.57)L、(2.43±0.75)L、(233.3±30.8)L/min;两组FEV1、FVC、VC及PEF比较差异有统计学意义(P<0.05)。结论特布他林联合糖皮质激素治疗慢阻肺急性加重期的患者可明显改善其气道功能,并提升其生活质量,疗效安全、可靠,值得推广应用。

Objective To analyze the effect of Glucocorticoid combined with Terbutaline on acute exacerbation of chronic obstructive pulmonary disease. Methods A total of 120 chronic obstructive pulmonary disease patients with acute exacerbation were divided into control group and research group according to the order of admission, 60 cases in each group. The control group was given Terbutaline for treatment, the research group was given Terbutaline combined with Glucocorticoid for treatment. The pulmonary function indexes [the forced expiratory volume in 1 st second（FEV1）, forced vital capacity（FVC）, vital capacity（VC） and peak expiratory flow（PEF）] before and after treatment between the two groups were compared. Results Before treatment, there were no statistically significant differences in the FEV1, FVC, VC and PEF between the two groups（P〉0.05）.After treatment, the FEV1, FVC, VC and PEF of the research group were（2.75±0.59） L,（3.26±0.82） L,（2.91± 0.84） L and（257.7±35.4） L/min respectively, which were significantly higher than（2.33±0.61） L,（2.85±0.57） L,（2.43±0.75） L and（233.3±30.8）L/min of the control group, the differences were statistically significant（P0.05）. Conclusion Terbutaline combined with Glucocorticoids in the treatment of chronic obstructive pulmonary disease patients with acute exacerbation can significantly improve their airway function and quality of life, the efficacy is safe and reliable, worthy of promotion and application.