Cell transplantation therapy using pluripotent stem cells

The 2012 Nobel Prize in Physiology or Medicine was awarded jointly to Sir John B Gurdon and Shinya Ya-manaka “for the discovery that mature cells can be re-programmed to become pluripotent”. Professor John B Gordon who pioneered the feld of somatic cell nuclear transfer was the frst to show that a nucleus of a ma-ture cell can be transplanted into an enucleated egg and give rise to a living organism. His pioneering “clon-ing” technique paved the way for genome reprogram-ming and has led to subsequent cloning of differentani-mal species. Professor Shinya Yamanaka revolutionized the fled of stem cell production by showing that the introduction of four selected genes into cells transform them into induced pluripotent stem cells that resemble embryonic stem cells and serve as promising cells for future regenerative medicine.

The 2012 Nobel Prize in Physiology or Medicine was awarded jointly to Sir John B Gurdon and Shinya Yamanaka "for the discovery that mature cells can be reprogrammed to become pluripotent". Professor John B Gordon who pioneered the field of somatic cell nuclear transfer was the first to show that a nucleus of a mature cell can be transplanted into an enucleated egg and give rise to a living organism. His pioneering "cloning" technique paved the way for genome reprogramming and has led to subsequent cloning of differentanimal species. Professor Shinya Yamanaka revolutionized the filed of stem cell production by showing that the introduction of four selected genes into cells transform them into induced pluripotent stem cells that resemble embryonic stem cells and serve as promising cells for future regenerative medicine.