胶质母细胞瘤中PLOD3的表达及临床意义

Expression of PLOD3 protein in gliobastoma and its clinical significance

目的探讨赖氨酸羟基化酶3(procollagen-lysine,2-oxoglutarate 5-dioxygenase 3,PLOD3)在胶质母细胞瘤中的表达及其临床意义。方法采用免疫组化法检测61例胶质母细胞瘤及40例正常脑组织中PLOD3蛋白的表达。分析PLOD3在胶质母细胞瘤中的表达与临床病理参数以及预后的关系。结果胶质母细胞瘤组织中PLOD3表达水平显著高于正常脑组织(均P <0. 05); PLOD3的表达在不同性别、不同年龄、不同KPS评分以及不同肿瘤体积的患者中差异无统计学意义(均P>0. 05),在肿瘤切除完整与否的患者中差异有统计学意义(P <0. 05)。PLOD3高表达与低表达的胶质母细胞瘤患者相比具有更短的生存期(P <0. 05)。结论 PLOD3在胶质母细胞瘤中高表达,并与预后相关,可能参与了胶质母细胞瘤的发生发展。

Objective To investigate the expression of PLOD3 in the gliobastoma（GBM） and its clinical significance. Methods Immnohistochemistry was used to detect PLOD3 protein expression level in 61 cases of GBM and 40 cases of normal brain tissue. The relationships between the expression of PLOD3 and the clinical pathological parameter of GBM were analyzed. Results The expression level of PLOD3 in GBM was significantly higher than that in normal brain tissue（ P 〈 0. 05 ）. Positive expression of PLOD3 was not correlated with age, gender, KPS assessment, and the tumor size, but correlated with subtotal resection（ P 〈 0. 05 ）. The overall survival time was significantly shorter in the patients with positive PLOD3 expression in GBM than those with negative expression（ P 〈 0. 05 ）. Conclusion PLOD3 is overexpressed in GBM,and it is correlated with poor survival,which suggest that it may be involved in GBM pro gression.