合并细菌感染的真菌球型鼻窦炎菌群分析

Analysis of bacterial flora offungal spherical rhinosinusitis with bacterial infection

目的分析不同年龄段真菌球型鼻窦炎鼻腔鼻窦菌群差异及药敏结果,为真菌球型鼻窦炎在围手术期选用抗生素进行预防感染提供用药依据。方法收集160例真菌球型鼻窦炎病例,根据年龄分为青年组、中年组、老年组,行鼻内镜手术时采集中鼻道及术区脓性分泌物,做细菌培养和药敏试验。结果青年组与中年组革兰阳性菌检出率无统计学差异,且致病菌均以革兰阳性菌为主;老年组患者革兰阴性菌检出率显著高于青年组和中年组,差异有统计学意义。结论对不同年龄段真菌球型鼻窦炎患者用药时,应充分考虑患者的年龄及药敏分析结果,根据不同年龄段的菌群差异,区别用药。

OBJECTIVE To analyze the difference of pathogenic bacterial flora and antimicrobial susceptibility infungal rhinosinusitis（fungal spherical） among different age groups, and to provide the basis for the use of antibiotics to prevent infection during perioperative period. METHODS160 cases of fungal rhinosinusitis（fungal spherical） were included and divided in three groups： young group, middle age group and elderly group. And the purulent secretions were collected during functional endoscopic sinus surgery to perform bacterial culture and drug sensitivity test. RESULTS There was no significant difference in the detection rate of Grampositive bacteria between the young group and the middle-aged group, and the main pathogenic bacteria were Gram-positive bacteria. The detection rate of Gram-negative bacteria in the elderly group was significantly higher than that in the young and middle-aged group. CONCLUSION The age of the patients and drug sensitivity offungal rhinosinusitis（fungal spherical） should be considered, and different drugs should be used according to different ages.