脑心通联合氨氯地平治疗高血压伴动脉粥样硬化疗效观察

Effect of Naoxintong Combined with Amlodipine on Hypertension Complicated with Atherosclerosis

目的:探讨脑心通联合氨氯地平治疗原发性高血压伴动脉粥样硬化的临床疗效。方法:200例随机分为2组。观察组给氨氯地平5mg口服,每天1次,联合脑心通胶囊4粒口服,每天3次;对照组给氨氯地平5mg口服,每天1次,疗程均为3个月。治疗前后观察2组患者的血压变化、颈动脉斑块面积、积分变化、颈动脉内膜中层厚度、血脂、血液黏稠度的变化。结果:2组治疗后,收缩压和舒张压较治疗前均有明显降低,但观察组优于对照组,(P<0.05),差异有统计学意义;观察组治疗后颈动脉IMT、斑块总面积及斑块积分均下降(P<0.05),差异有统计学意义;TG、TC、LDL-C水平观察组较对照组有明显降低(P<0.05),差异有统计学意义,HDL-C水平观察组较对照组有明显升高(P<0.05),差异有统计学意义。不良反应发生率2组差异无统计学意义。结论:脑心通联合氨氯地平能有效调控血压,降低血液血脂水平,降低血液黏稠度,具有"类他汀"药物的抗动脉粥样硬化作用,且无明显不良反应,值得临床推广应用。

Objective： To investigate the clinical efficacy of Naoxintong combined with amlodipine in the treatment of essential hypertension with atherosclerosis. Methods： 200 patients were randomly divided into observation group and control group. The observation group gave amlodipine 5mg orally once a day, and combined with 4 capsules of Naoxin- tong Capsules, 3 times a day. The control group was given amlodipine 5 mg orally once a day for 3 months. Changes in blood pressure, carotid plaque area, integral changes, carotid intima-media thickness, blood lipids, and blood viscosity were observed before and after treatment. RESULTS： After treatment, systolic blood pressure and diastolic blood pres- sure were significantly lower than those before treatment, but the observation group was superior to the control group （P〈0.05）. The difference was statistically significant. Carotid IMT, total plaque area and plaque scores were decreased in the observation group after treatment （P〈0.05）, and the difference was statistically significant. The TG, TC, and LDL-C levels were significantly lower in the observation group than in the control group （P〈0.05）, and the difference was statistically significant. The HDL-C level observation group was significantly higher than the control group （P〈0.05）, and the difference was statistically significant. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion： Naoxintong combined with amlodipine can effectively regulate blood pressure, lower blood lipid levels and reduce obvious adverse reactions, which is blood viscosity. It has anti-atherosclerosis worthy of clinical annlication_ effect of statin-hke drugs, and has no