三维多平面切面法自动评估胎儿脑部发育的可行性研究

Feasibility of Automatic Three-Dimensional Slice in Evaluationof Fetal Brain Development

目的:探讨三维多平面切面法(3D slice)自动测量正常孕晚期胎儿脑部体积及其随孕周变化的可行性。方法:选择MRI3D-FIESTA检查孕周为30~39周脑部正常发育胎儿各10例共100例,利用人工智能软件构建三维模型并自动计算胎儿大脑体积,小脑体积,分析所得数值与孕周的关系。结果:100例均自动测量成功。胎儿大脑体积,小脑体积,小脑体积/大脑体积均随孕周增大而增加,小脑容积增长更快。结论:3D slice可作为一种新的自动评估胎儿脑部发育情况的方法。

Purpose： To assess the feasibility of three dimensional slice （3D slice） in evaluating the regional brain volume changes of normal fetuses. Methods： MRI images of 100 fetuses at 30-39 weeks gestational age were collected, 3D model of 2 brain regions （cerebrum and cerebellum） were automatically reconstructed and their volumes were measured. Correlations between volumes and their gestational age were assessed using regression models. Results： 3D slice acquisitions were successful in all fetuses. Cerebrum and cerebellum were increased in absolute volume during the gestation period, and the rate of cerebellar growth was higher. Conclusion： 3D slice is useful in assessing the fetal brain development.