舒痛饮治疗急性痛风性关节炎临床疗效观察

Clinical Observation of Shutong Yin for Treatment of Acute Gouty Arthritis

【目的】观察舒痛饮(半枫荷、金钱草、救必应、川牛膝、布渣叶、两面针等组成)治疗急性痛风性关节炎的临床疗效。【方法】将72例急性痛风性关节炎患者随机分为治疗组和对照组,每组各36例。对照组给予秋水仙碱治疗,治疗组给予舒痛饮治疗,7 d为1个疗程,连续治疗2个疗程。比较2组患者治疗前后中医证候评分、疼痛视觉模拟量表(VAS)评分和红细胞沉降率(ESR)、C-反应蛋白(CRP)、血尿酸(UA)等实验室指标的变化情况,并评价2组的临床疗效及安全性。【结果】(1)治疗2个疗程后,治疗组总有效率为97.22%,对照组为91.67%,2组总有效率及总体疗效比较,差异均无统计学意义(P>0.05)。(2)治疗后,2组患者的中医证候评分、VAS疼痛评分均较治疗前改善(P<0.05),且治疗组对中医证候评分及VAS疼痛评分的改善作用均优于对照组(P<0.05)。(3)治疗后,2组患者的ESR、CRP、UA等各项实验室指标均较治疗前明显改善(P<0.05),且治疗组对各项指标的改善作用均优于对照组(P<0.05)。(4)治疗过程中,治疗组无明显不良反应病例出现,对照组有5例出现恶心、纳差等胃肠道反应;2组患者的不良反应情况比较,差异有统计学意义(P<0.05)。【结论】舒痛饮治疗急性痛风性关节炎具有较好疗效,可有效改善患者的临床症状及疼痛评分,降低患者的ESR、CRP、UA等相关实验室指标。

Objective To observe the clinical effect of Shutong Yin for the treatment of acute gouty arthritis.Methods A total of 72 patients with acute gouty arthritis were randomly divided into treatment group and controlgroup,36 cases in each group. The control group was treated with oral use of colchicine,and the observationgroup was treated with oral use of Shutong Yin,7 days constituting one treatment course,the treatment lasted 2 treatment courses. Before and after treatment,the traditional Chinese medicine（TCM）syndrome scores,visualanalogue scale（VAS）pain scores,and laboratory indexes such as erythrocyte sedimentation rate（ESR）,C-reactive protein（CRP）and blood uric acid（UA）in the two groups were observed. After treatment,the clinicalefficacy and safety of the two groups were evaluated. Results After 2 treatment courses,the total effective rate inthe treatment group was 97.22%,and was 91.67% in the control group. There were no significant differences of thetotal effective rate and overall clinical effect between the two groups（P 〉 0.05）.（2）After treatment, TCMsyndrome scores and VAS pain scores in the two groups were improved as compared with those before treatment（P 〈 0.05）,the improvement in the treatment group being superior to that in the control group（P 〈 0.05）.（3）After treatment,the laboratory indexes of ESR,CRP and UA in the two groups were improved as compared withthose before treatment（P 〈 0.05）,the improvement in the treatment group being superior to that in the controlgroup（P 〈 0.05）.（4）During the treatment,no obvious adverse reactions in the treatment group were found,but 5 cases in the control group had gastrointestinal reactions of nausea and loss of appetite. The differences of adversereaction between the two groups were significant（P 〈 0.05）. Conclusion Shutong Yin has satisfactory clinical effectfor acute gouty arthritis by effectively improving clinical symptoms and pain scores, and lowering the related laboratory indexes including ESR,CRP and UA.