针灸治疗肠易激综合征的作用机制研究进展

Progress of Studies on Therapeutic Mechanism of Acup-moxibustion Therapy for Irritable Bowel Syndrome

综述近年来针灸治疗肠易激综合征作用机制的研究文献,总结针灸治疗IBS疗效机制主要通过如下途径:(1)通过交感神经调节肠道应激反应,调节肠道功能和肠道运动;(2)通过神经内分泌途径影响其他神经递质的分泌,其中一条途径即通过脑—肠轴有效调节脑肠肽如P物质(SP)、血管活性肠肽(vasoactive intestinal peptide, VIP)、胆囊收缩素(cholecystokinin,CCK)、一氧化氮(nitric oxide,NO)、胃动素(motilin,MTL)、生长抑素(somatostatin,SS)、5-羟色胺(5-hydroxytryptamine,5-HT)等的分泌。提示针灸疗法防治肠易激综合征的疗效明确,对肠道动力、内脏高敏感性、脑肠肽、神经系统、免疫系统等均有较好的调节作用。

The achievements of therapeutic mechanism research of acup-moxibustion therapy for irritable bowel syndrome（IBS）in recent years were reviewed. The therapeutic mechanism of acup-moxibustion therapy for IBSinvolved the following pathways：（1）acup-moxibustion therapy had an effect on stress reaction of the intestines throughsympathetic nerve, thus to regulate the intestinal function and intestinal movement;（2）acup-moxibustiontherapy had an effect on the secretion of neurotransimitters such as substance P（SP）,vasoactive intestinal peptide（VIP）,cholecystokinin（CCK）,nitric oxide（NO）, motilin（MTL）,somatostatin（SS）,and 5-hydroxytryptamine（5-HT）through brain-gut axis. It is indicated that acup-moxibustion therapy is effective for the treatment of IBS,and exerts certain regulatory effects on intestinal motility,visceral hypersensitivity,brain-gut peptide,nervous system,immune system and other aspects.