糖尿病性视网膜病变患者视网膜中央血管血流动力学的改变

Changes of haemodynamic parameters of the central retinal vessels in patients with diabetic retinopathy

目的观察糖尿病性视网膜病变（DR）患者视网膜中央血管血流动力学参数的改变。方法对不合并DR的糖尿病66例（117只眼，DM组）、DR98例（181只眼，DR组）和老年性白内障或屈光不正68例（136只眼，对照组）进行前瞻性病例对照研究。结果分析三组患者视网膜中央动脉直径（P=0．000）和血流速度（P=0．000）、视网膜中央静脉血流速度（P=0．000）、搏动指数（P=0．025）、阻力指数（P=0．0007）差异有统计学意义。结论DM和DR患者的视网膜中央血管血流动力学参数均有改变，提示视网膜中央血管在DR的发生机制中可能起到一定作用。

Objective To observe the changes of haemodynamic parameters of the central retinal vessels in patients with diabetic retinopathy （DR）. Methods Prospective observational case-control study. The data of 117 eyes of 66 diabetic patients without DR, 181 eyes of 98 patients with DR, and 136 eyes of 68 cases with senile cataract or ametropia were analyzed. Results The differences were significant in diameter （ P = 0. 000） and blood velocity （ P = 0. 000 ） of the central retinal artery, blood velocity of the central retinal vein （ P = 0.000 ） , pulsatility index （ P = 0. 025 ） , and resistivity index （ P = 0. 0007 ） among the three groups. Conclusion There are changes of baemodynamic parameters of the central retinal vessels in diabetic and DR patients. The central retinal vessels may play a role in the pathogenesis of DR.