CDT联合机械碎栓治疗DVT的疗效较好、安全性高

CDT Combined with Mechanical Thrombectomy is Effective and Safe in the Treatment of DVT

为探讨导管溶栓（CDT）联合机械碎栓术治疗下肢深静脉血栓（DVT）的疗效及对患者凝血功能的影响，本研究选取我院诊治的120例DVT患者进行回顾性分析，收集时间为2014年11月至2016年1月，根据治疗方法分为CDT组（单纯CDT治疗）和联合组（CDT联合机械碎栓术治疗）各60例，对比两组的治疗效果及对患者凝血功能的影响。研究结果显示，治疗前，联合组和CDT组患者的大腿患侧健侧差值、小腿患侧健侧差值差异均无统计学意义（p〉0．05）；治疗后，联合组患者的大腿患侧健侧差值、小腿患侧健侧差值显著的小于CDT组（p〈0．05），两组患者的大腿患侧健侧差值、小腿患侧健侧差值较治疗前均显著的减小（p〈0．05）；治疗后，联合组患者的深静脉通畅率91．67％，显著高于CDT组患者的76．67％（p〈0．05）；溶栓前，联合组和CDT组患者的R、K、α角、MA值差异均无统计学意义（p〉0.05）；溶栓48h、96h时，联合组患者的R、K值显著的小于CDT组（p〈0.05），联合组患者的仪角、MA值均大于CDT组（p〈0．05）；在溶栓48h、96h时，两组患者的R、K值较溶栓前显著的增高（p〈0.05），两组患者的仅角、MA值较溶栓前显著的降低（p〈0.05）；联合组患者的并发症率为6．67％显著低于CDT组患者的20．00％（p〈0．05）。本研究表明CDT联合机械碎栓术治疗DVT的效果更好，同时对患者凝血功能的影响更小，出血风险较小。

In order to investigate the efficacy of transcatheter thrombolysis （CDT） combined with mechanical thrombectomy for lower extremity deep venous thrombosis （DVT） and its effect on coagulation function, 120 cases of DVT patients in our hospital were retrospectively analyzed from November 2014 to January 2016, divided them into CDT group （CDT alone） and combination group （CDT combined with mechanical thrombectomy therapy） according to the methods of treatment, each group contained 60 patients. The research compared treatment effect and influence on coagulation function in patients between two groups. The results shown that before treatment, there was no significant difference in the difference between the healthy side and thigh side of the thigh between the combination group and the CDT grou （p〉0.05）. The difference between the healthy side of the thigh and the healthy side of the lower leg was significantly less in the combination group than in the CDT group （p〈0.05）. The difference between the healthy side and thigh side of the two groups were significantly decreased compared with those before treatment （p 〈0.05）. After treatment, the rate of deep vein patency in the combination group was 91.67%, which was significantly higher than that in the CDT group （76.67%） （p〈0.05）. Before thrombolysis, there was no significant difference in the value of R, K, α angle and MA between the combination group and the CDT group （p 〉0.05）. After thrombolysis 48 h and 96 h, the R and K values of the combination group were significantly lessthan those of the CDT group （p〈0.05）. The et angle and MA values of the patients in the combination group were greater than those in the CDT group （p〈0.05）. In thrombolysis of 48 h and 96 h, the R and K values of the two groups were significantly higher than those before thrombolysis; after thrombolysis 48 h and 96 h, the R and K values of the combined group were significantly less than those of the CDT group （/9 〈0.05）. The ~ angle and MA values of the two groups were significantly lower than those before thrombolysis （t9 〈0.05）. The complication rate of the combination group was 6.67%, which was significantly lower than that of the CDT group （20%） （p〈0.05）. The research indicated that CDT combined with mechanical thrombectomy was more effective in the treatment of DVT, and has less influence on coagulation function and reduces the risk of bleeding.