不同剂量口服碘对甲亢患者的治疗效果评价

Evaluation of the Therapeutic Effect of Different Doses of Oral Iodine on Hyperthyroidism

为探究不同剂量口服碘对甲状腺功能亢进患者的治疗效果与影响，本研究选取荆州市第一人民医院在2011年9月至2015年2月收治的120例甲亢患者，随机分为观察组（n=60）和对照组（n=60），给予观察组患者d,N量113服碘进行治疗，人均剂量为2．85MBq／g；给予对照组患者大剂量口服碘进行治疗，人均剂量为4．47MBq／g，观察比较两组患者血清内促甲状腺激素（TSH）、四碘甲状腺原氨酸（T4）、游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）、三碘甲状腺原氨酸（T3）水平的变化，以此评价甲状腺功能减退的发生率及治疗效果。研究结果显示，观察组患者的总有效率为96．67％，对照组为76．67％；观察组患者甲状腺功能降低的发生率为1．67％，对照组为16．67％，观察组的疗效显著优于对照组，差异具有统计学意义（p〈0．05）。经治疗后，两组患者血清内的FT3、FT4、T3及T4水平均显著降低，TSH水平明显高，差异具有统计学意义（p〈0.05），但治疗后观察组和对照组两组患者血清内的T3、T4、FT3、FT4和TSH水平均无显著差异（p〉0．05）。研究表明，小剂量口服碘能够有效治疗甲状腺功能亢进，且小剂量碘能够降低甲亢的发生率，疗效显著，值得临床广泛应用。

To explore different doses of oral iodine effect on the treatment of patients with thyroid function hyperfunction, this study selected 120 cases of patients with hyperthyroidism in Jingzhou First People＇s Hospital in September 2011 to February 2015, which were randomly divided into observation group （n=60） and control group （n=60）. Observation group of patients were treated with low doses of oral iodine at 2.85 per capita MBq/g; Control group patients were treated with high-dose of oral iodine, dose per capita is 4.47 MBq/g, changes in serum TSH, T4, FT4, FT3 and T3 levels were observed and compared between the two groups to evaluate the incidence and therapeutic effect of hypothyroidism. The results showed that the total effective rate was 96.67% in the observation group and 76.67% in the control group. The incidence of hypothyroidism in the observation group was 1.67%, while that in the control group was 16.67%. The efficacy of the observation group was significantly better than that in the control group, and the difference was statistically significant （p 〈0.05）. After treatment, the serum levels of FT3, FT4, T3 and T4 in the two groups of patients were significantly reduced and TSH level was significantly higher （p〈0.05）, but the serum levels of T3, T4, FT3, FT4 and TSH were not significantly different between the observation group and the control group （p〉0.05）. The research indicated that small doses of oral iodine could effectively treat hyperthyroidism, and small doses of iodine could reduce the incidence of hyperthyroidism, which has a significant effect and is worthy of wide clinical application.