醒脑静联合纳洛酮治疗脑出血昏迷患者的疗效及对MBP、NSE的影响

Effect of Xingnaojing Combined with Naloxone on Cerebral Hemorrhage Coma Patients and Its Effect on MBP and NSE

为探讨醒脑静、纳洛酮联合治疗脑出血昏迷患者的疗效及对血清髓鞘碱性蛋白（MBP）、血清神经元特异性烯醇化酶（NSE）水平的影响，本研究选取2015年2月至2017年2月本院收治的脑出血昏迷患者88例，根据治疗方法不同，随机分为对照组和观察组。对照组患者采用常规治疗并联合纳洛酮的治疗方式，观察组在对照组基础上联合醒脑静治疗，分析两组患者治疗后临床疗效。结果显示：治疗前，两组患者GCS评分、NIHSS评分、脑血肿量均无明显差异69〉0．05）。在治疗7d、14d后，与对照组比较，观察组患者GCS评分明显升高，NIHSS评分则明显降低，脑血肿量也明显减少（p〈0．05）。治疗前，两组患者MBP、NSE、HMGB-1及GFAP水平比较无统计学差异（p〉0．05）。治疗14d后，观察组患者MBP、NSE、HMGB-1及GFAP水平均低于对照组（p〈0．05）。本研究表明醒脑静、纳洛酮联合治疗脑出血昏迷患者具有显著疗效，可改善患者的意识障碍，通过降低患者血清中MBP、NSE、HMGB-1和GFAP水平，减轻神经损伤，促进神经功能的恢复。

To investigate the efficacy of Xingnaojing and Naloxone in the treatment ofintracerebral haemorrhage coma patients and the effect on serum MBP and serum neuron-specific enolase （NSE） levels. In this study, 88 patients with intracerebral haemorrhage coma who were admitted to our hospital from February 2015 to February 2017 were selected and randomly divided into control group and observation group according to different treatment methods. Patients in the control group were treated with conventional therapy and combined with naloxone treatment. The observation group was combined with Xingnaojing treatment on the basis of the control group. Clinical efficacy after treatment was analyzed in both groups. The results showed that before treatment, there was no significant difference in GCS score, NIHSS score, and intracerebral haemorrhage volume between the two groups （p〉0.05）. After 7 days and 14 days of treatment, compared with the control group, the GCS score in the observation group was significantly higher, the NIHSS score was significantly lower, and the intracerebral haemorrhage volume was also significantly reduced （p〈0.05）. Before treatment, the levels of MBP, NSE, HMGB-1, and GFAP were not statistically different between the two groups （p〉0.05）. After 14 days of treatment, the levels of MBP, NSE, HMGB-1, and GFAP were lower in the observation group than in the control group （p 〈0.05）. This study shows thatXingnaojing and naloxone combined therapy for intracerebral haemorrhage coma patients have a significant effect, can improve the patient＇s consciousness disorders, reduce the level of MBP, NSE, HMGB-1 and GFAP in the serum of patients, reduce nerve damage, and promote nerve function Recovery.