牛奶能否预防酒精性胃溃疡的研究

Whether Milk could Prevent Alcoholic Gastric Ulcer

胃溃疡是全球范围内的常见疾病，酒精是引起胃溃疡的常见诱因之一。民间多有关于饮用牛奶后饮酒可有效减少酒精对胃部损伤的说法，但这一说法并未经过科学验证。本研究利用小鼠建立胃溃疡模型，通过组织观察和病理切片，从时问梯度和剂量梯度两个方向研究牛奶是否对酒精性胃溃疡存在防护作用。结果表明，随时间梯度的增加，灌胃低剂量无水乙醇的个体会出现两极分化现象，部分个体胃溃疡程度逐步增加，而另一些个体在连续灌胃的第5天出现完全的自愈合。高剂量酒精引起的胃部充血、溃疡程度和面积高于中剂量组。模型组（仅灌胃无水乙醇）和实验组（灌胃牛奶后再灌胃无水乙醇）均出现黏膜结构紊乱及脱落现象。不论是时间梯度还是剂量梯度，预先服用牛奶的实验组其胃溃疡面积及程度与仅服用酒精的模型组相比，均无显著差异。研究结果表明牛奶对于酒精性胃溃疡并无防护作用。

Gastric ulcer is a common disease across the world and alcohol is one of the major causes of gastric ulcer. There is a word in folk that drinking after taking milk can decrease the damage of alcohol to gastric, however, such word is not scientifically identified. This research employs small rats to establish alcoholic gastric ulcer model and conducts microstmcture observation and pathological section to research whether the milk has protective effect to alcoholic gastric ulcer through time gradient and dosage gradient. The results show that with the increase of time gradient, the individuals with low dosage absolute ethylalcohol intragastric administration have polarization phenomenon that partial individuals＇gastric ulcer degree increases and some others have complete self- healing at the fifth day of continual intragastric administration. The gastric hypermia, ulcer degree and area caused by high dosage alcohol are higher than mid- dosage group. Both individuals with absolute ethyl alcohol intragastric administration and individuals with milk intragastric administration and then absolute ethyl alcohol intragastric administration have the phenomena of mucosa structure confusion and mucosa structure falling. The gastric ulcer areas and degrees of experimental group with advanced milking drinking and of model group with only alcohol drinking have no significant difference in time gradient or dosage gradient. Above research results show that the milk has no protective effect to alcoholic gastric ulcer.