喉接触性肉芽肿的发病机制及治疗

Pathogenesis and treatment of laryngeal contact granuloma

喉接触性肉芽肿(laryngeal contact granuloma,LCG),也称为声带突肉芽肿或喉接触性溃疡,是由于各种原因导致的声带突周围黏膜损伤及溃疡反复发作,进一步组织增生形成的肉芽肿样病变。该疾病发病机制尚不明确,常见于持续性声带压迫、咽喉反流以及有长期清嗓史的人群。具有难治愈、易复发的特点。临床上部分患者常出现药物治疗无效、无法耐受药物治疗或反复手术后复发及后续的治疗方案难以抉择等问题。因此针对不同患者选择个体化治疗方案非常重要。本文将重点对LCG的发病机制及不同治疗手段进行综述与总结,为个体化治疗的选择提供依据。

Laryngeal contact granuloma,also known as vocal fold granuloma,contact granuloma or contact ulcer of larynx,refers to mucosal lesions with concurrent inflammatory reaction and ulceration around the vocal process caused by various kinds of diseases and incentives. With unclear pathogenesis,it occurs most frequently in the patients with sustained increased pressure on the vocal folds,laryngopharyngeal reflux,and habitual throat clearing. And it has a high propensity for persistence and recurrence. Invalid medical treatment,medical intolerance and postoperative recurrence occurred frequently. Therefore,the individualized treatment regimen is important. This paper summarizes the pathogenesis of and treatment means for laryngeal contact granuloma to provide basis for the choice of individualized treatment.