功能化离子液体[C_3SO_3Hnhm]HSO_4催化合成苯并氧杂蒽

Synthesis of benzoxanthene catalyzed by functionalized ionic liquids [C_3SO_3Hnhm] HSO_4

无溶剂下以功能化酸性离子液体4-(3-磺丙基)吗啡啉硫酸氢盐([C_3SO_3Hnhm]HSO_4)为催化剂,催化β-萘酚和芳香醛合成苯并氧杂蒽。通过单因素试验和正交试验优化反应条件,并考察了该离子液体的重复使用性能。结果表明,当苯甲醛用量为0. 005 mol,β-萘酚与苯甲醛摩尔比为2∶1,催化剂用量为苯甲醛的6%,100℃下反应10 min后苯并氧杂蒽的产率达到91%以上。[C_3SO_3Hnhm]HSO_4催化剂重复使用5次,其催化活性下降不明显,为苯并氧杂蒽类化合物的绿色合成提供了一种新方法。

A solvent - free synthesis of benzoxanthene was operated, in which functionalized acidic ionic liquids, 4 - （3 - propanesulfonic acid） morphinehydrogen sulfate [ C3 SO3 Hnhm ] HSO4 were used as catalysts, and β-naphthol and aromatic aldehyde were used as raw materials. The reaction conditions were optimized by the single factor experiment and orthogonal experiment,and the reusability of the ionic liquid catalyst was also studied. The results show that when the dosage of benzaldehyde is 0.005 mol, the molar ratio of β - naphthol to benzaldehyde is 2：1, and the catalyst is in an amount corresponding to 6% of benzaldehyde, the yield can reach more than 91% after reaction for 10 min at 100℃. The catalytic activity of [ C3 SO3 Hnhm ] HSO4 was not significantly reduced for being reused 5 times. This work has provided a new method for green synthesis of benzoxanthene compounds.